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• W2020207911 endingPage "736" @default.
• W2020207911 startingPage "725" @default.
• W2020207911 abstract "Alpha(1)-microglobulin is a 26 kDa plasma and tissue glycoprotein that belongs to the lipocalin protein superfamily. Recent reports show that it is a reductase and radical scavenger and that it binds heme and has heme-degrading properties. This study has investigated the protective effects of alpha(1)-microglobulin against oxidation by heme and reactive oxygen species in the human erythroid cell line, K562. The results show that alpha(1)-microglobulin prevents intracellular oxidation and up-regulation of heme oxygenase-1 induced by heme, hydrogen peroxide and Fenton reaction-generated hydroxyl radicals in the culture medium. It also reduces the cytosol of non-oxidized cells. Endogeneous expression of alpha(1)-microglobulin was up-regulated by these oxidants and silencing of the alpha(1)-microglobulin expression increased the cytosol oxidation. alpha(1)-microglobulin also inhibited cell death caused by heme and cleared cells from bound heme. Binding of heme to alpha(1)-microglobulin increased the radical reductase activity of the protein as compared to the apo-protein. Finally, alpha(1)-microglobulin was localized mainly at the cell surface both when administered exogeneously and in non-treated cells. The results suggest that alpha(1)-microglobulin is involved in the defence against oxidative cellular injury caused by haemoglobin and heme and that the protein may employ both heme-scavenging and one-electron reduction of radicals to achieve this." @default.
• W2020207911 created "2016-06-24" @default.
• W2020207911 creator A5019782300 @default.
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• W2020207911 date "2008-01-01" @default.
• W2020207911 modified "2023-09-24" @default.
• W2020207911 title "The lipocalin<i>α</i>₁-microglobulin protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen species" @default.
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• W2020207911 doi "https://doi.org/10.1080/10715760802337265" @default.
• W2020207911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18712632" @default.
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