FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020209643> ?p ?o ?g. }

• W2020209643 endingPage "e1000034" @default.
• W2020209643 startingPage "e1000034" @default.
• W2020209643 abstract "Alzheimer disease is characterized by abnormal protein deposits in the brain, such as extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made of a protein called tau comprising 441 residues in its longest isoform. Tau belongs to the class of natively unfolded proteins, binds to and stabilizes microtubules, and partially folds into an ordered β-structure during aggregation to Alzheimer paired helical filaments (PHFs). Here we show that it is possible to overcome the size limitations that have traditionally hampered detailed nuclear magnetic resonance (NMR) spectroscopy studies of such large nonglobular proteins. This is achieved using optimal NMR pulse sequences and matching of chemical shifts from smaller segments in a divide and conquer strategy. The methodology reveals that 441-residue tau is highly dynamic in solution with a distinct domain character and an intricate network of transient long-range contacts important for pathogenic aggregation. Moreover, the single-residue view provided by the NMR analysis reveals unique insights into the interaction of tau with microtubules. Our results establish that NMR spectroscopy can provide detailed insight into the structural polymorphism of very large nonglobular proteins." @default.
• W2020209643 created "2016-06-24" @default.
• W2020209643 creator A5004740429 @default.
• W2020209643 creator A5033249566 @default.
• W2020209643 creator A5037375841 @default.
• W2020209643 creator A5039594034 @default.
• W2020209643 creator A5047141760 @default.
• W2020209643 creator A5051485155 @default.
• W2020209643 creator A5067807223 @default.
• W2020209643 creator A5072290405 @default.
• W2020209643 date "2009-02-17" @default.
• W2020209643 modified "2023-10-01" @default.
• W2020209643 title "Structural Polymorphism of 441-Residue Tau at Single Residue Resolution" @default.
• W2020209643 cites W126863785 @default.
• W2020209643 cites W150987474 @default.
• W2020209643 cites W1525659758 @default.
• W2020209643 cites W1680110353 @default.
• W2020209643 cites W1963525648 @default.
• W2020209643 cites W1963791487 @default.
• W2020209643 cites W1965887195 @default.
• W2020209643 cites W1969952127 @default.
• W2020209643 cites W1975040221 @default.
• W2020209643 cites W1976638865 @default.
• W2020209643 cites W1978668412 @default.
• W2020209643 cites W1984770038 @default.
• W2020209643 cites W1989847819 @default.
• W2020209643 cites W1995562130 @default.
• W2020209643 cites W1997477098 @default.
• W2020209643 cites W1998177378 @default.
• W2020209643 cites W2001443225 @default.
• W2020209643 cites W2003119577 @default.
• W2020209643 cites W2006192061 @default.
• W2020209643 cites W2006199861 @default.
• W2020209643 cites W2006520473 @default.
• W2020209643 cites W2007829343 @default.
• W2020209643 cites W2015795135 @default.
• W2020209643 cites W2021914048 @default.
• W2020209643 cites W2022417585 @default.
• W2020209643 cites W2023193162 @default.
• W2020209643 cites W2024041849 @default.
• W2020209643 cites W2026771024 @default.
• W2020209643 cites W2027652753 @default.
• W2020209643 cites W2032576201 @default.
• W2020209643 cites W2034286717 @default.
• W2020209643 cites W2034942377 @default.
• W2020209643 cites W2036008741 @default.
• W2020209643 cites W2039069312 @default.
• W2020209643 cites W2039270622 @default.
• W2020209643 cites W2048367443 @default.
• W2020209643 cites W2061172155 @default.
• W2020209643 cites W2073486807 @default.
• W2020209643 cites W2074586183 @default.
• W2020209643 cites W2074952395 @default.
• W2020209643 cites W2078658743 @default.
• W2020209643 cites W2079615523 @default.
• W2020209643 cites W2082608241 @default.
• W2020209643 cites W2089618587 @default.
• W2020209643 cites W2092818861 @default.
• W2020209643 cites W2097891553 @default.
• W2020209643 cites W2104034347 @default.
• W2020209643 cites W2112103709 @default.
• W2020209643 cites W2114185596 @default.
• W2020209643 cites W2117526022 @default.
• W2020209643 cites W2117863623 @default.
• W2020209643 cites W2117931147 @default.
• W2020209643 cites W2119598236 @default.
• W2020209643 cites W2124019813 @default.
• W2020209643 cites W2124597092 @default.
• W2020209643 cites W2125172225 @default.
• W2020209643 cites W2125389879 @default.
• W2020209643 cites W2127229268 @default.
• W2020209643 cites W2127888335 @default.
• W2020209643 cites W2128536686 @default.
• W2020209643 cites W2136637949 @default.
• W2020209643 cites W2137772676 @default.
• W2020209643 cites W2142366168 @default.
• W2020209643 cites W2144925005 @default.
• W2020209643 cites W2148521301 @default.
• W2020209643 cites W2149472608 @default.
• W2020209643 cites W2155952058 @default.
• W2020209643 cites W2169821755 @default.
• W2020209643 cites W2170671445 @default.
• W2020209643 cites W2185039370 @default.
• W2020209643 cites W232800751 @default.
• W2020209643 cites W240415867 @default.
• W2020209643 cites W278916191 @default.
• W2020209643 cites W285886331 @default.
• W2020209643 cites W53635167 @default.
• W2020209643 cites W69856591 @default.
• W2020209643 doi "https://doi.org/10.1371/journal.pbio.1000034" @default.
• W2020209643 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2642882" @default.
• W2020209643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19226187" @default.
• W2020209643 hasPublicationYear "2009" @default.
• W2020209643 type Work @default.
• W2020209643 sameAs 2020209643 @default.
• W2020209643 citedByCount "504" @default.
• W2020209643 countsByYear W20202096432012 @default.
• W2020209643 countsByYear W20202096432013 @default.

• next