FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020210694> ?p ?o ?g. }

• W2020210694 endingPage "188" @default.
• W2020210694 startingPage "179" @default.
• W2020210694 abstract "Background:The expression of CD204 on macrophages in the stroma of the primary tumor is reportedly correlated with an unfavorable prognosis for lung cancer. The purpose of this study is to investigate the correlation among the number of CD204+ tumor–associated macrophages infiltrating the stroma of the primary tumor, the number of circulating CD14+CD204+ cells from the pulmonary vein (PV), and recurrence-free probability in non–small-cell lung cancer patients.Methods:Human mononuclear cells were isolated from the PV of resected lungs. We examined the expressions of CD14 and CD204 on these cells by flow cytometry. Immunohistochemical staining for CD204 was performed in the resected specimens.Results:The number of CD14+CD204+ cells from the PV was found to be correlated with the number of CD204+ tumor–associated macrophages identified in the stroma of the tumor. Significantly more cases with high levels of CD14+CD204+ cells from the PV were found to have developed early recurrences. CD14+CD204+ cells, which were polarized to the tumor-promoting phenotype cultured in lung cancer cell line–conditioned medium, facilitated the lung metastasis of cancer cells more effectively than CD14+CD204− cells in our in vivo mouse model. In multivariate analysis, only the high number of CD14+CD204+ cells from the PV was found to be a statistically significant independent risk factor for early recurrence.Conclusion:Our results showed the possibility that circulating CD14+CD204+ cells contribute to the metastasis of cancer cells. The blockage of circulating CD14+CD204+ cells activity may prevent postoperative recurrence in resected non–small-cell lung cancer patients. The expression of CD204 on macrophages in the stroma of the primary tumor is reportedly correlated with an unfavorable prognosis for lung cancer. The purpose of this study is to investigate the correlation among the number of CD204+ tumor–associated macrophages infiltrating the stroma of the primary tumor, the number of circulating CD14+CD204+ cells from the pulmonary vein (PV), and recurrence-free probability in non–small-cell lung cancer patients. Human mononuclear cells were isolated from the PV of resected lungs. We examined the expressions of CD14 and CD204 on these cells by flow cytometry. Immunohistochemical staining for CD204 was performed in the resected specimens. The number of CD14+CD204+ cells from the PV was found to be correlated with the number of CD204+ tumor–associated macrophages identified in the stroma of the tumor. Significantly more cases with high levels of CD14+CD204+ cells from the PV were found to have developed early recurrences. CD14+CD204+ cells, which were polarized to the tumor-promoting phenotype cultured in lung cancer cell line–conditioned medium, facilitated the lung metastasis of cancer cells more effectively than CD14+CD204− cells in our in vivo mouse model. In multivariate analysis, only the high number of CD14+CD204+ cells from the PV was found to be a statistically significant independent risk factor for early recurrence. Our results showed the possibility that circulating CD14+CD204+ cells contribute to the metastasis of cancer cells. The blockage of circulating CD14+CD204+ cells activity may prevent postoperative recurrence in resected non–small-cell lung cancer patients." @default.
• W2020210694 created "2016-06-24" @default.
• W2020210694 creator A5015841589 @default.
• W2020210694 creator A5028439535 @default.
• W2020210694 creator A5038375140 @default.
• W2020210694 creator A5046015782 @default.
• W2020210694 creator A5069595627 @default.
• W2020210694 creator A5069717236 @default.
• W2020210694 creator A5069799858 @default.
• W2020210694 creator A5091584502 @default.
• W2020210694 date "2014-02-01" @default.
• W2020210694 modified "2023-09-27" @default.
• W2020210694 title "Circulating CD14+CD204+ Cells Predict Postoperative Recurrence in Non–Small-Cell Lung Cancer Patients" @default.
• W2020210694 cites W1480357432 @default.
• W2020210694 cites W1975815647 @default.
• W2020210694 cites W1990791836 @default.
• W2020210694 cites W2001717792 @default.
• W2020210694 cites W2010715204 @default.
• W2020210694 cites W2035278966 @default.
• W2020210694 cites W2040773741 @default.
• W2020210694 cites W2041600831 @default.
• W2020210694 cites W2048270768 @default.
• W2020210694 cites W2050636009 @default.
• W2020210694 cites W2066469619 @default.
• W2020210694 cites W2075006354 @default.
• W2020210694 cites W2099040029 @default.
• W2020210694 cites W2100834680 @default.
• W2020210694 cites W2101995865 @default.
• W2020210694 cites W2109017823 @default.
• W2020210694 cites W2116554142 @default.
• W2020210694 cites W2127168600 @default.
• W2020210694 cites W2127342594 @default.
• W2020210694 cites W2146530991 @default.
• W2020210694 cites W2158234609 @default.
• W2020210694 cites W2171433554 @default.
• W2020210694 doi "https://doi.org/10.1097/jto.0000000000000044" @default.
• W2020210694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24419414" @default.
• W2020210694 hasPublicationYear "2014" @default.
• W2020210694 type Work @default.
• W2020210694 sameAs 2020210694 @default.
• W2020210694 citedByCount "22" @default.
• W2020210694 countsByYear W20202106942014 @default.
• W2020210694 countsByYear W20202106942015 @default.
• W2020210694 countsByYear W20202106942016 @default.
• W2020210694 countsByYear W20202106942017 @default.
• W2020210694 countsByYear W20202106942018 @default.
• W2020210694 countsByYear W20202106942019 @default.
• W2020210694 countsByYear W20202106942020 @default.
• W2020210694 countsByYear W20202106942021 @default.
• W2020210694 countsByYear W20202106942022 @default.
• W2020210694 crossrefType "journal-article" @default.
• W2020210694 hasAuthorship W2020210694A5015841589 @default.
• W2020210694 hasAuthorship W2020210694A5028439535 @default.
• W2020210694 hasAuthorship W2020210694A5038375140 @default.
• W2020210694 hasAuthorship W2020210694A5046015782 @default.
• W2020210694 hasAuthorship W2020210694A5069595627 @default.
• W2020210694 hasAuthorship W2020210694A5069717236 @default.
• W2020210694 hasAuthorship W2020210694A5069799858 @default.
• W2020210694 hasAuthorship W2020210694A5091584502 @default.
• W2020210694 hasBestOaLocation W20202106941 @default.
• W2020210694 hasConcept C121608353 @default.
• W2020210694 hasConcept C126322002 @default.
• W2020210694 hasConcept C142724271 @default.
• W2020210694 hasConcept C203014093 @default.
• W2020210694 hasConcept C2776256026 @default.
• W2020210694 hasConcept C2778513237 @default.
• W2020210694 hasConcept C2779013556 @default.
• W2020210694 hasConcept C502942594 @default.
• W2020210694 hasConcept C553184892 @default.
• W2020210694 hasConcept C71924100 @default.
• W2020210694 hasConceptScore W2020210694C121608353 @default.
• W2020210694 hasConceptScore W2020210694C126322002 @default.
• W2020210694 hasConceptScore W2020210694C142724271 @default.
• W2020210694 hasConceptScore W2020210694C203014093 @default.
• W2020210694 hasConceptScore W2020210694C2776256026 @default.
• W2020210694 hasConceptScore W2020210694C2778513237 @default.
• W2020210694 hasConceptScore W2020210694C2779013556 @default.
• W2020210694 hasConceptScore W2020210694C502942594 @default.
• W2020210694 hasConceptScore W2020210694C553184892 @default.
• W2020210694 hasConceptScore W2020210694C71924100 @default.
• W2020210694 hasIssue "2" @default.
• W2020210694 hasLocation W20202106941 @default.
• W2020210694 hasLocation W20202106942 @default.
• W2020210694 hasLocation W20202106943 @default.
• W2020210694 hasOpenAccess W2020210694 @default.
• W2020210694 hasPrimaryLocation W20202106941 @default.
• W2020210694 hasRelatedWork W1499339123 @default.
• W2020210694 hasRelatedWork W1967103478 @default.
• W2020210694 hasRelatedWork W2032912323 @default.
• W2020210694 hasRelatedWork W2372561159 @default.
• W2020210694 hasRelatedWork W2375344515 @default.
• W2020210694 hasRelatedWork W2390152934 @default.
• W2020210694 hasRelatedWork W2908335280 @default.
• W2020210694 hasRelatedWork W3173207637 @default.
• W2020210694 hasRelatedWork W3200600991 @default.
• W2020210694 hasRelatedWork W4304116770 @default.
• W2020210694 hasVolume "9" @default.
• W2020210694 isParatext "false" @default.

• next