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- W2020218903 abstract "Estrogen biosynthesis during human pregnancy has been studied by examination of the radioactive urinary metabolites excreted following the intravenous administration of isotope-labelled steroids to pregnant women under a variety of conditions. Dehydroisoandrosterone sulfate has been shown to be efficiently converted to estrogen in women pregnant with a hydatidiform mole, an anencephalic fetus, and a normal fetus. The fraction of dehydroisoandrosterone sulfate converted to ‘estradiol’ ranged from 4 to 55 per cent. Under certain conditions a major portion of the total endogenous estrogen production may arise by this means. In addition, several lines of evidence indicate that estriol may be derived from dehydroisoandrosterone sulfate by a biochemical pathway which does not involve estrone or estradiol. It is concluded that the placenta does not exclusively utilize de novo mechanisms for estrogen production and may, in fact, rely entirely upon externally supplied steroidal precursors." @default.
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- W2020218903 title "The utilization of circulating dehydroisoandrosterone sulfate for estrogen synthesis during human pregnancy" @default.
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