Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020220205> ?p ?o ?g. }
- W2020220205 endingPage "357" @default.
- W2020220205 startingPage "351" @default.
- W2020220205 abstract "Recent studies have illustrated the importance of placental drug transport proteins, such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in limiting fetal exposure to drugs and toxins. Moreover, increasing evidence supports a role for Pgp and BCRP in the normal development and physiological function of the placenta. Several single nucleotide polymorphisms (SNPs) in the genes encoding Pgp and BCRP have been described and are associated with altered protein expression, transporter activity, and clinical outcome in studies focusing on tissues other than the placenta. This review aims to summarize current research regarding the association between these polymorphisms and expression and function in the placenta. The influence of these genotypes on fetal drug exposure and altered placental physiology or development is also presented. To date, evidence suggests that SNPs in both ABCB1 and ABCG1 can alter expression of their respective protein; however, the functional significance of these polymorphisms is less clear. An understanding of this genotype–phenotype relationship will allow for prediction of susceptible or favorable genotypes in order to personalize medication choices to minimize fetal exposure to teratogens, or to maximize pharmacological therapy to the fetus." @default.
- W2020220205 created "2016-06-24" @default.
- W2020220205 creator A5026206882 @default.
- W2020220205 creator A5071104811 @default.
- W2020220205 creator A5071397090 @default.
- W2020220205 date "2010-05-01" @default.
- W2020220205 modified "2023-09-24" @default.
- W2020220205 title "Placental P-glycoprotein and breast cancer resistance protein: Influence of polymorphisms on fetal drug exposure and physiology" @default.
- W2020220205 cites W123422070 @default.
- W2020220205 cites W1480389906 @default.
- W2020220205 cites W1493933632 @default.
- W2020220205 cites W1866641948 @default.
- W2020220205 cites W1965127293 @default.
- W2020220205 cites W1966368641 @default.
- W2020220205 cites W1968808154 @default.
- W2020220205 cites W1973268592 @default.
- W2020220205 cites W1978953108 @default.
- W2020220205 cites W1981810228 @default.
- W2020220205 cites W1986585175 @default.
- W2020220205 cites W1990474450 @default.
- W2020220205 cites W1993337516 @default.
- W2020220205 cites W1999304753 @default.
- W2020220205 cites W2001067238 @default.
- W2020220205 cites W2002795755 @default.
- W2020220205 cites W2013995823 @default.
- W2020220205 cites W2018546188 @default.
- W2020220205 cites W2021031411 @default.
- W2020220205 cites W2022892231 @default.
- W2020220205 cites W2025334711 @default.
- W2020220205 cites W2026449959 @default.
- W2020220205 cites W2032410140 @default.
- W2020220205 cites W2037057915 @default.
- W2020220205 cites W2037472613 @default.
- W2020220205 cites W2042910761 @default.
- W2020220205 cites W2043730183 @default.
- W2020220205 cites W2044935825 @default.
- W2020220205 cites W2045333505 @default.
- W2020220205 cites W2052209393 @default.
- W2020220205 cites W2052229830 @default.
- W2020220205 cites W2055437362 @default.
- W2020220205 cites W2059584690 @default.
- W2020220205 cites W2061773900 @default.
- W2020220205 cites W2062577889 @default.
- W2020220205 cites W2065072706 @default.
- W2020220205 cites W2067274784 @default.
- W2020220205 cites W2068605087 @default.
- W2020220205 cites W2069791449 @default.
- W2020220205 cites W2070691527 @default.
- W2020220205 cites W2074803927 @default.
- W2020220205 cites W2074918235 @default.
- W2020220205 cites W2075284437 @default.
- W2020220205 cites W2075293629 @default.
- W2020220205 cites W2083418897 @default.
- W2020220205 cites W2087412283 @default.
- W2020220205 cites W2091958366 @default.
- W2020220205 cites W2092419590 @default.
- W2020220205 cites W2095908153 @default.
- W2020220205 cites W2097683711 @default.
- W2020220205 cites W2098938825 @default.
- W2020220205 cites W2104409728 @default.
- W2020220205 cites W2104711019 @default.
- W2020220205 cites W2110060881 @default.
- W2020220205 cites W2113283528 @default.
- W2020220205 cites W2117944128 @default.
- W2020220205 cites W2118207487 @default.
- W2020220205 cites W2118667947 @default.
- W2020220205 cites W2125820808 @default.
- W2020220205 cites W2133287244 @default.
- W2020220205 cites W2136930977 @default.
- W2020220205 cites W2141597037 @default.
- W2020220205 cites W2143229545 @default.
- W2020220205 cites W2143341711 @default.
- W2020220205 cites W2147580246 @default.
- W2020220205 cites W2148042336 @default.
- W2020220205 cites W2150815388 @default.
- W2020220205 cites W2151957104 @default.
- W2020220205 cites W2156157049 @default.
- W2020220205 cites W2162994727 @default.
- W2020220205 cites W2163636362 @default.
- W2020220205 cites W2164258524 @default.
- W2020220205 cites W2166153381 @default.
- W2020220205 cites W2289603230 @default.
- W2020220205 cites W2319135466 @default.
- W2020220205 cites W4232195096 @default.
- W2020220205 doi "https://doi.org/10.1016/j.placenta.2010.02.010" @default.
- W2020220205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20347140" @default.
- W2020220205 hasPublicationYear "2010" @default.
- W2020220205 type Work @default.
- W2020220205 sameAs 2020220205 @default.
- W2020220205 citedByCount "36" @default.
- W2020220205 countsByYear W20202202052012 @default.
- W2020220205 countsByYear W20202202052013 @default.
- W2020220205 countsByYear W20202202052014 @default.
- W2020220205 countsByYear W20202202052015 @default.
- W2020220205 countsByYear W20202202052016 @default.
- W2020220205 countsByYear W20202202052017 @default.
- W2020220205 countsByYear W20202202052018 @default.
- W2020220205 countsByYear W20202202052019 @default.