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- W2020223592 abstract "Although it is clear that dopamine (DA) can affect PRL and GH release at the level ofthe hypothalamus and median eminence⁄pituitary gland, the relative importance of the site of control remains unclear. Consequently, we differentially altered central or peripheral DA levelsby administering L-dopa (250 mg) orally to six healthy male volunteers after pretreatment with theperipheral decarboxylase inhibitor carbidopa (central action), iv DA (4 µg⁄kg-min,peripheral action),and L-dopa (500 mg orally, both central and peripheral actions). The changes inGHand PRL observed were correlated with the concentrations of L-dopa and DA measured by the radioenzymatic technique. Peak L-dopa and DA levels were 1.2 ± 0.3 jug⁄ml and 8.4 ± 1.9 ng⁄ml after L-dopa and 2.5 ± 0.6 jug⁄ml and 1.7 ± 0.5 ng⁄ml, respectively, when half the L-dopa dose was combined with carbidopa. While DA and L-dopa concentrations were significantly correlated after L-dopa (r = 0.9), this relationship was abolished by carbidopa.Peak GH levels were comp..." @default.
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- W2020223592 date "1981-08-01" @default.
- W2020223592 modified "2023-10-16" @default.
- W2020223592 title "Dopaminergic Regulation of Growth Hormone (GH) Secretion in Normal Man: Correlationof L-Dopa and Dopamine Levels with the GH Response*" @default.
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- W2020223592 doi "https://doi.org/10.1210/jcem-53-2-301" @default.
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