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• W2020228093 abstract "The severity of neutropenia in myelodysplastic syndrome (MDS) has not been completely studied. We analyzed the prognostic significance of severe neutropenia (neutrophils count < 0.5 × 109/L) at diagnosis in 1109 patients with de novo MDS and low/intermediate-1 IPSS included in the Spanish MDS Registry. Severe neutropenia was present at diagnosis in 48 of 1109 (4%). Patients with severe neutropenia were most strongly represented within the groups of refractory cytopenia with multilineage dysplasia (40%) and refractory anemia with excess of blast type 1 (29%). Severe neutropenia had negative effects on the low/intermediate-1 risk group. A significant difference in overall survival was observed between patients with severe neutropenia (28 months) and patients with a neutrophil count higher than 0.5 × 109/L (66 months) (p < 0.0001). Also, severe neutropenia predicted a significantly reduced on leukemia-free survival (p < 0.0001). In the multivariate analysis, severe neutropenia retained its independent prognostic influence on overall survival [HR: 2.19, 95% CI (1.41–3.10), p < 0.0001] and leukemia free survival [HR: 3.51, 95% CI (1.97–6.26), p < 0.0001]. The degree of neutropenia should be considered as additional prognostic factor in low/intermediate-1 IPSS MDS." @default.
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• W2020228093 date "2012-03-01" @default.
• W2020228093 modified "2023-10-17" @default.
• W2020228093 title "The degree of neutropenia has a prognostic impact in low risk myelodysplastic syndrome" @default.
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• W2020228093 doi "https://doi.org/10.1016/j.leukres.2011.10.025" @default.
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