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- W2020230845 abstract "1. SCH 23390 (SCH, R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) produced the relaxation of ACh-induced contraction in the anterior byssus retractor muscle of Mytilus edulis (ABRM) in a dose-dependent manner between 10−9-10−6M. 2. The dose-response curve of SCH was shifted in parallel to the right by ketanserin (KET) with pA2 value of 5.14 ± 0.08 and by 1-(1-naphthyl)piperazine (NAP) with that of 5.06 ± 0.01, but not by cyproheptadine (CYP), mianserin (MIA), butaclamol (BUTA), ICS 205–930 (ICS) and MDL 72222 (MDL) at 3 × 10−5 M. 3. α-Methyl-serotonin (α-Me-5-HT), a selective 5-HT2 receptor agonist dose-dependently relaxed the ACh-induced contraction of ABRM. The dose-response curve of α-Me-5-HT was shifted in parallel to the right by KET with pA2 value of 5.01 ± 0.02, but not by BUTA, CYP, MIA, ICS and MDL at 3 × 10−5 M. 4. These findings suggest that 5-HT2-like receptors exist in the ABRM, and that the relaxation induced by SCH is mediated through these receptors." @default.
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- W2020230845 date "1989-01-01" @default.
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- W2020230845 title "The relaxing effect of SCH 23390 in the molluscan smooth muscle" @default.
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- W2020230845 doi "https://doi.org/10.1016/0742-8413(89)90189-8" @default.
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