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• W2020235727 abstract "Background In HIV-infected patients on long-term HAART, virus persistence in resting long-lived CD4 T cells is a major barrier to curing the infection. Cell quiescence, by favouring HIV latency, reduces the risk of recognition and cell destruction by cytotoxic lymphocytes. Several cell-activation-based approaches have been proposed to disrupt cell quiescence and then virus latency, but these approaches have not eradicated the virus. CD4+CD25+ regulatory T cells (Tregs) are a CD4+ T-cell subset with particular activation properties. We investigated the role of these cells in virus persistence in patients on long-term HAART. Methodology/Principal Findings We found evidence of infection of resting Tregs (HLADR−CD69−CD25hiFoxP3+CD4+ T cells) purified from patients on prolonged HAART. HIV DNA harbouring cells appear more abundant in the Treg subset than in non-Tregs. The half-life of the Treg reservoir was estimated at 20 months. Since Tregs from patients on prolonged HAART showed hyporesponsiveness to cell activation and inhibition of HIV-specific cytotoxic T lymphocyte-related functions upon activation, therapeutics targeting cell quiescence to induce virus expression may not be appropriate for purging the Treg reservoir. Conclusions Our results identify Tregs as a particular compartment within the latent reservoir that may require a specific approach for its purging." @default.
• W2020235727 created "2016-06-24" @default.
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• W2020235727 date "2008-10-01" @default.
• W2020235727 modified "2023-09-26" @default.
• W2020235727 title "Resting Regulatory CD4 T Cells: A Site of HIV Persistence in Patients on Long-Term Effective Antiretroviral Therapy" @default.
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• W2020235727 doi "https://doi.org/10.1371/journal.pone.0003305" @default.
• W2020235727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2551739" @default.
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