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- W2020236005 abstract "<b>Objective </b>To study the effects of HMME-based photodynamic therapy on proliferation and apoptosis of rabbit vascular smooth muscle cells(VSMCs). <b>Method</b> The cytotoxic effect of HMME-PDT on rabbit vascular smooth muscle cells was studied by means of Trypan Blue assay, HMME at 10&mgr;g/ml concentration and the light dose at 2.4~4.8 J/cm<sup>2</sup> were selected in the studies. The morphological character 24h post-PDT was investigated by HE Staining. Annexin V and propidium iodide (PI) binding assays were performed to analyze the characteristics of cell death after HMME-PDT. Furthermore, The intracellular distributions of the HMME were measured by the confocal laser scanning microscope. <b>Result</b> It was showed the photocytotoxity to VSMC cells was dose related by Trypan Blue assay. Histology observing suggests HMME-PDT could induce cell death through apoptosis or necrosis, and the apoptosic rate was up to 50.5% by AnnexinV /PI assay. Moreover, the fluorescence images of HMME intracellular localization demonstrated that the HMME diffused into the mitochondria. <b>Conclusion</b> HMME-PDT could significantly inhibite VSMC proliferation and induce apoptosis." @default.
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- W2020236005 date "2007-02-08" @default.
- W2020236005 modified "2023-09-23" @default.
- W2020236005 title "The apoptosis induced by HMME-based photodynamic therapy in rabbit vascular smooth muscle cells" @default.
- W2020236005 doi "https://doi.org/10.1117/12.702042" @default.
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