FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020242791> ?p ?o ?g. }

• W2020242791 endingPage "180" @default.
• W2020242791 startingPage "174" @default.
• W2020242791 abstract "HIV-1 infection of the central nervous system (CNS) is associated with dysregulation of several important cytokines and chemokines, which are involved in inflammatory process. Earlier studies ascribed a critical role for Tat, a potent viral transcription activator, in this process by enhancing the expression of several immunomodulators including TGFbeta and MCP-1. Investigation of signaling pathways which are controlled by these cytokines led to identification of MH2 domain of Smad3, the downstream activator of TGFbeta pathway, as a modulator of MCP-1 promoter activity. The level of MCP-1 is increased in AIDS patients with neurologic problems, through recruitment of inflammatory cells, which can contribute to neuropathogenesis of AIDS. Therefore, we attempted to investigate the effect of MH2 on expression of MCP-1 and other immunolmodulators in CNS cells. By employing an adenovirus expression vector, we demonstrated that MH2 can decrease the levels of Tat-induced activation of MCP-1 and several other cytokines and chemokines in astrocytic cells. In addition, we showed that MH2 significantly reduced the activity of cytokines produced by cultures of adenovirus-MH2 transduced cells as measured by the transmigration of human PBMC cells. Thus, MH2 domain of Smad3 is a potential agent that may be developed as an inhibitor for the cytokine-mediated inflammatory responses in the brain and may have the potential to prevent transmigration of HIV-1-infected monocytes across the blood brain barrier in AIDS patients." @default.
• W2020242791 created "2016-06-24" @default.
• W2020242791 creator A5028766520 @default.
• W2020242791 creator A5030144974 @default.
• W2020242791 creator A5055427599 @default.
• W2020242791 creator A5072360221 @default.
• W2020242791 creator A5072693351 @default.
• W2020242791 creator A5091117281 @default.
• W2020242791 date "2006-07-01" @default.
• W2020242791 modified "2023-09-24" @default.
• W2020242791 title "MH2 domain of Smad3 reduces HIV-1 Tat-induction of cytokine secretion" @default.
• W2020242791 cites W1489789360 @default.
• W2020242791 cites W1604626968 @default.
• W2020242791 cites W1868711871 @default.
• W2020242791 cites W1962437344 @default.
• W2020242791 cites W1971592398 @default.
• W2020242791 cites W1971864431 @default.
• W2020242791 cites W1972800880 @default.
• W2020242791 cites W1974863401 @default.
• W2020242791 cites W1981634406 @default.
• W2020242791 cites W1988722391 @default.
• W2020242791 cites W1990965304 @default.
• W2020242791 cites W2001634471 @default.
• W2020242791 cites W2001669885 @default.
• W2020242791 cites W2002254372 @default.
• W2020242791 cites W2005567038 @default.
• W2020242791 cites W2011740000 @default.
• W2020242791 cites W2014439767 @default.
• W2020242791 cites W2020586880 @default.
• W2020242791 cites W2021151285 @default.
• W2020242791 cites W2026926920 @default.
• W2020242791 cites W2029288933 @default.
• W2020242791 cites W2037753264 @default.
• W2020242791 cites W2038843757 @default.
• W2020242791 cites W2040753051 @default.
• W2020242791 cites W2052900571 @default.
• W2020242791 cites W2053053546 @default.
• W2020242791 cites W2068397982 @default.
• W2020242791 cites W2069414088 @default.
• W2020242791 cites W2076498141 @default.
• W2020242791 cites W2086419987 @default.
• W2020242791 cites W2087423729 @default.
• W2020242791 cites W2089289162 @default.
• W2020242791 cites W2089883535 @default.
• W2020242791 cites W2093946365 @default.
• W2020242791 cites W2099644089 @default.
• W2020242791 cites W2105522078 @default.
• W2020242791 cites W2138902434 @default.
• W2020242791 cites W2140121036 @default.
• W2020242791 cites W2142529927 @default.
• W2020242791 cites W2155388660 @default.
• W2020242791 cites W2168225085 @default.
• W2020242791 cites W2175674051 @default.
• W2020242791 doi "https://doi.org/10.1016/j.jneuroim.2006.04.004" @default.
• W2020242791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16750572" @default.
• W2020242791 hasPublicationYear "2006" @default.
• W2020242791 type Work @default.
• W2020242791 sameAs 2020242791 @default.
• W2020242791 citedByCount "11" @default.
• W2020242791 countsByYear W20202427912012 @default.
• W2020242791 countsByYear W20202427912015 @default.
• W2020242791 countsByYear W20202427912020 @default.
• W2020242791 crossrefType "journal-article" @default.
• W2020242791 hasAuthorship W2020242791A5028766520 @default.
• W2020242791 hasAuthorship W2020242791A5030144974 @default.
• W2020242791 hasAuthorship W2020242791A5055427599 @default.
• W2020242791 hasAuthorship W2020242791A5072360221 @default.
• W2020242791 hasAuthorship W2020242791A5072693351 @default.
• W2020242791 hasAuthorship W2020242791A5091117281 @default.
• W2020242791 hasConcept C13373296 @default.
• W2020242791 hasConcept C134018914 @default.
• W2020242791 hasConcept C137061746 @default.
• W2020242791 hasConcept C169760540 @default.
• W2020242791 hasConcept C170493617 @default.
• W2020242791 hasConcept C202751555 @default.
• W2020242791 hasConcept C203014093 @default.
• W2020242791 hasConcept C2776914184 @default.
• W2020242791 hasConcept C2778690821 @default.
• W2020242791 hasConcept C49039625 @default.
• W2020242791 hasConcept C529278444 @default.
• W2020242791 hasConcept C55493867 @default.
• W2020242791 hasConcept C86803240 @default.
• W2020242791 hasConcept C88045685 @default.
• W2020242791 hasConcept C95444343 @default.
• W2020242791 hasConceptScore W2020242791C13373296 @default.
• W2020242791 hasConceptScore W2020242791C134018914 @default.
• W2020242791 hasConceptScore W2020242791C137061746 @default.
• W2020242791 hasConceptScore W2020242791C169760540 @default.
• W2020242791 hasConceptScore W2020242791C170493617 @default.
• W2020242791 hasConceptScore W2020242791C202751555 @default.
• W2020242791 hasConceptScore W2020242791C203014093 @default.
• W2020242791 hasConceptScore W2020242791C2776914184 @default.
• W2020242791 hasConceptScore W2020242791C2778690821 @default.
• W2020242791 hasConceptScore W2020242791C49039625 @default.
• W2020242791 hasConceptScore W2020242791C529278444 @default.
• W2020242791 hasConceptScore W2020242791C55493867 @default.
• W2020242791 hasConceptScore W2020242791C86803240 @default.
• W2020242791 hasConceptScore W2020242791C88045685 @default.

• next