Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020255255> ?p ?o ?g. }
- W2020255255 endingPage "916" @default.
- W2020255255 startingPage "910" @default.
- W2020255255 abstract "Our study focuses on the design and synthesis of a new piperazinic derivate, 4-(1-phenyl-1h-Pyrazol-4-Ylmethyl)-Piperazine-1-Carboxylic Acid Ethyl ester (LQFM008), and evaluation of its anxiolytic-like profile in Swiss mice. LQFM008 was evaluated in a screening test of the central nervous system including the rota-rod, sodium pentobarbital-induced sleep, open field, elevated plus maze and light–dark box tests. LQFM008 induced convulsions at the dose of 1.1 mmol/kg (i.p., s.c. or p.o.). LQFM008 up to 400 μmol/kg had no effect in the rota rod test. In the open field test, LQFM008 increased the number of crossings and the time spent at the central area as well as the sleeping time in sodium pentobarbital-induced sleep. In the elevated plus maze and light–dark box tests, this compound showed an anxiolytic-like activity. This anxiolytic-like activity was antagonized by NAN-190 (5-HT1A antagonist) but not by flumazenil (benzodiazepine antagonist). The compound LQFM008 showed anxiolytic-like activity which may involve serotonergic pathway." @default.
- W2020255255 created "2016-06-24" @default.
- W2020255255 creator A5003052957 @default.
- W2020255255 creator A5007770033 @default.
- W2020255255 creator A5013804074 @default.
- W2020255255 creator A5058070797 @default.
- W2020255255 creator A5071367022 @default.
- W2020255255 creator A5073378252 @default.
- W2020255255 creator A5075209868 @default.
- W2020255255 date "2012-06-01" @default.
- W2020255255 modified "2023-10-12" @default.
- W2020255255 title "Central pharmacological activity of a new piperazine derivative: 4-(1-Phenyl-1h-pyrazol-4-ylmethyl)-piperazine-1-carboxylic acid ethyl ester" @default.
- W2020255255 cites W1966037459 @default.
- W2020255255 cites W1968292606 @default.
- W2020255255 cites W1970267926 @default.
- W2020255255 cites W1976049732 @default.
- W2020255255 cites W1978865301 @default.
- W2020255255 cites W1982569952 @default.
- W2020255255 cites W1986929497 @default.
- W2020255255 cites W2000583301 @default.
- W2020255255 cites W2011378558 @default.
- W2020255255 cites W2012937095 @default.
- W2020255255 cites W2013082402 @default.
- W2020255255 cites W2018021139 @default.
- W2020255255 cites W2018946923 @default.
- W2020255255 cites W2025429408 @default.
- W2020255255 cites W2032058764 @default.
- W2020255255 cites W2037102395 @default.
- W2020255255 cites W2041561931 @default.
- W2020255255 cites W2043097850 @default.
- W2020255255 cites W2043886872 @default.
- W2020255255 cites W2046682807 @default.
- W2020255255 cites W2048009786 @default.
- W2020255255 cites W2050258439 @default.
- W2020255255 cites W2056028845 @default.
- W2020255255 cites W2059231973 @default.
- W2020255255 cites W2073924899 @default.
- W2020255255 cites W2075405478 @default.
- W2020255255 cites W2078974273 @default.
- W2020255255 cites W2079224783 @default.
- W2020255255 cites W2079714688 @default.
- W2020255255 cites W2088391380 @default.
- W2020255255 cites W2102460175 @default.
- W2020255255 cites W2105125003 @default.
- W2020255255 cites W2133977192 @default.
- W2020255255 cites W2147419610 @default.
- W2020255255 cites W2179208644 @default.
- W2020255255 cites W2952240294 @default.
- W2020255255 doi "https://doi.org/10.1016/j.lfs.2012.04.037" @default.
- W2020255255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22564406" @default.
- W2020255255 hasPublicationYear "2012" @default.
- W2020255255 type Work @default.
- W2020255255 sameAs 2020255255 @default.
- W2020255255 citedByCount "16" @default.
- W2020255255 countsByYear W20202552552013 @default.
- W2020255255 countsByYear W20202552552014 @default.
- W2020255255 countsByYear W20202552552015 @default.
- W2020255255 countsByYear W20202552552016 @default.
- W2020255255 countsByYear W20202552552017 @default.
- W2020255255 countsByYear W20202552552018 @default.
- W2020255255 countsByYear W20202552552020 @default.
- W2020255255 countsByYear W20202552552022 @default.
- W2020255255 countsByYear W20202552552023 @default.
- W2020255255 crossrefType "journal-article" @default.
- W2020255255 hasAuthorship W2020255255A5003052957 @default.
- W2020255255 hasAuthorship W2020255255A5007770033 @default.
- W2020255255 hasAuthorship W2020255255A5013804074 @default.
- W2020255255 hasAuthorship W2020255255A5058070797 @default.
- W2020255255 hasAuthorship W2020255255A5071367022 @default.
- W2020255255 hasAuthorship W2020255255A5073378252 @default.
- W2020255255 hasAuthorship W2020255255A5075209868 @default.
- W2020255255 hasBestOaLocation W20202552551 @default.
- W2020255255 hasConcept C118552586 @default.
- W2020255255 hasConcept C134018914 @default.
- W2020255255 hasConcept C170493617 @default.
- W2020255255 hasConcept C173586616 @default.
- W2020255255 hasConcept C185592680 @default.
- W2020255255 hasConcept C2775864247 @default.
- W2020255255 hasConcept C2776201271 @default.
- W2020255255 hasConcept C2776755955 @default.
- W2020255255 hasConcept C2776885963 @default.
- W2020255255 hasConcept C2777765862 @default.
- W2020255255 hasConcept C2778173252 @default.
- W2020255255 hasConcept C2778409475 @default.
- W2020255255 hasConcept C2779085643 @default.
- W2020255255 hasConcept C37000724 @default.
- W2020255255 hasConcept C55493867 @default.
- W2020255255 hasConcept C558461103 @default.
- W2020255255 hasConcept C71924100 @default.
- W2020255255 hasConcept C98274493 @default.
- W2020255255 hasConceptScore W2020255255C118552586 @default.
- W2020255255 hasConceptScore W2020255255C134018914 @default.
- W2020255255 hasConceptScore W2020255255C170493617 @default.
- W2020255255 hasConceptScore W2020255255C173586616 @default.
- W2020255255 hasConceptScore W2020255255C185592680 @default.
- W2020255255 hasConceptScore W2020255255C2775864247 @default.
- W2020255255 hasConceptScore W2020255255C2776201271 @default.
- W2020255255 hasConceptScore W2020255255C2776755955 @default.