FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020256551> ?p ?o ?g. }

• W2020256551 endingPage "712" @default.
• W2020256551 startingPage "703" @default.
• W2020256551 abstract "Haploidentical hematopoietic stem cell transplantation (HSCT) constitutes an important alternative for patients lacking a human leukocyte antigen (HLA)-matched donor. Although the use of haploidentical donors is increasingly common, the long-term impact of generating a donor-derived immune system in the context of an HLA-mismatched thymic environment remains poorly characterized. We performed an in-depth assessment of immune reconstitution in a group of haploidentical HSCT recipients 4 to 6 years posttransplantation, in parallel with the respective parental donors and age-matched healthy control subjects. Our data show that the proportion of naive and memory subsets in the recipients, both within CD8+ and CD4+ T cells, more closely resembled that observed in age-matched control subjects than in the donors. HSCT recipients displayed relatively high signal-joint T cell–receptor excision circle levels and a high frequency of the recent thymic emigrant–enriched CD31+ subset within naive CD4+ and naive regulatory T cells. Moreover, CD8+, CD4+, and regulatory T cells from HSCT recipients displayed a diverse T cell repertoire. These results support a key role for thymic output in T cell reconstitution. Nevertheless, HSCT recipients had significantly shorter telomeres within a naive-enriched CD4+ T cell population than age-matched control subjects, despite the similar telomere length observed within the most differentiated CD8+ and CD4+ T cell subsets. Overall, our data suggest that long-term immune reconstitution was successfully achieved after haploidentical HSCT, a process that appears to have largely relied on de novo T cell production." @default.
• W2020256551 created "2016-06-24" @default.
• W2020256551 creator A5020723917 @default.
• W2020256551 creator A5021030728 @default.
• W2020256551 creator A5021249910 @default.
• W2020256551 creator A5031101116 @default.
• W2020256551 creator A5051793876 @default.
• W2020256551 creator A5076177499 @default.
• W2020256551 creator A5083847410 @default.
• W2020256551 creator A5084277682 @default.
• W2020256551 creator A5087498175 @default.
• W2020256551 creator A5055878897 @default.
• W2020256551 date "2013-05-01" @default.
• W2020256551 modified "2023-09-27" @default.
• W2020256551 title "Long-Term Immune Reconstitution of Naive and Memory T Cell Pools after Haploidentical Hematopoietic Stem Cell Transplantation" @default.
• W2020256551 cites W1544307647 @default.
• W2020256551 cites W1548372537 @default.
• W2020256551 cites W1580217007 @default.
• W2020256551 cites W1586815424 @default.
• W2020256551 cites W1652988747 @default.
• W2020256551 cites W1932492060 @default.
• W2020256551 cites W1942062259 @default.
• W2020256551 cites W1975393671 @default.
• W2020256551 cites W1978891933 @default.
• W2020256551 cites W1980740578 @default.
• W2020256551 cites W1981690705 @default.
• W2020256551 cites W1982247089 @default.
• W2020256551 cites W1985266927 @default.
• W2020256551 cites W1988181926 @default.
• W2020256551 cites W1993026821 @default.
• W2020256551 cites W1997333834 @default.
• W2020256551 cites W2009523265 @default.
• W2020256551 cites W2012221707 @default.
• W2020256551 cites W2028402895 @default.
• W2020256551 cites W2036736974 @default.
• W2020256551 cites W2036858642 @default.
• W2020256551 cites W2042997234 @default.
• W2020256551 cites W2048175139 @default.
• W2020256551 cites W2050921203 @default.
• W2020256551 cites W2051947926 @default.
• W2020256551 cites W2052468427 @default.
• W2020256551 cites W2054710330 @default.
• W2020256551 cites W2057432053 @default.
• W2020256551 cites W2059239713 @default.
• W2020256551 cites W2067211970 @default.
• W2020256551 cites W2074181748 @default.
• W2020256551 cites W2074259682 @default.
• W2020256551 cites W2079501748 @default.
• W2020256551 cites W2093213870 @default.
• W2020256551 cites W2095348090 @default.
• W2020256551 cites W2095616499 @default.
• W2020256551 cites W2105345404 @default.
• W2020256551 cites W2110706510 @default.
• W2020256551 cites W2111951140 @default.
• W2020256551 cites W2115135044 @default.
• W2020256551 cites W2116381276 @default.
• W2020256551 cites W2119411875 @default.
• W2020256551 cites W2123434358 @default.
• W2020256551 cites W2123799384 @default.
• W2020256551 cites W2125550036 @default.
• W2020256551 cites W2125701590 @default.
• W2020256551 cites W2126302947 @default.
• W2020256551 cites W2127395835 @default.
• W2020256551 cites W2129196766 @default.
• W2020256551 cites W2130040182 @default.
• W2020256551 cites W2142234156 @default.
• W2020256551 cites W2142821156 @default.
• W2020256551 cites W2158511680 @default.
• W2020256551 cites W2165981943 @default.
• W2020256551 cites W2170352596 @default.
• W2020256551 cites W2270536249 @default.
• W2020256551 cites W2323634856 @default.
• W2020256551 cites W4365410999 @default.
• W2020256551 doi "https://doi.org/10.1016/j.bbmt.2013.01.017" @default.
• W2020256551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23396243" @default.
• W2020256551 hasPublicationYear "2013" @default.
• W2020256551 type Work @default.
• W2020256551 sameAs 2020256551 @default.
• W2020256551 citedByCount "27" @default.
• W2020256551 countsByYear W20202565512013 @default.
• W2020256551 countsByYear W20202565512014 @default.
• W2020256551 countsByYear W20202565512015 @default.
• W2020256551 countsByYear W20202565512016 @default.
• W2020256551 countsByYear W20202565512017 @default.
• W2020256551 countsByYear W20202565512018 @default.
• W2020256551 countsByYear W20202565512019 @default.
• W2020256551 countsByYear W20202565512020 @default.
• W2020256551 countsByYear W20202565512021 @default.
• W2020256551 countsByYear W20202565512022 @default.
• W2020256551 countsByYear W20202565512023 @default.
• W2020256551 crossrefType "journal-article" @default.
• W2020256551 hasAuthorship W2020256551A5020723917 @default.
• W2020256551 hasAuthorship W2020256551A5021030728 @default.
• W2020256551 hasAuthorship W2020256551A5021249910 @default.
• W2020256551 hasAuthorship W2020256551A5031101116 @default.
• W2020256551 hasAuthorship W2020256551A5051793876 @default.
• W2020256551 hasAuthorship W2020256551A5055878897 @default.
• W2020256551 hasAuthorship W2020256551A5076177499 @default.

• next