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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020258510> ?p ?o ?g. }

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• W2020258510 abstract "Following the discovery of diketoacid-containing compounds as HIV-1 integrase (IN) inhibitors, a plethora of new molecules have been published leading to four drugs under clinical trial. In an attempt to rationally design new dimeric diketoacids (DKAs) targeting two divalent metal ions on the active site of IN, potent inhibitors against purified IN were found with varied selectivity for strand transfer. In this context, we designed and synthesized a new series of catechol–DKA hybrids. These compounds presented micromolar anti-integrase activities with moderate antiviral properties." @default.
• W2020258510 created "2016-06-24" @default.
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• W2020258510 date "2006-05-01" @default.
• W2020258510 modified "2023-10-18" @default.
• W2020258510 title "Design, synthesis, and anti-integrase activity of catechol–DKA hybrids" @default.
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• W2020258510 doi "https://doi.org/10.1016/j.bmc.2005.12.039" @default.
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