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- W2020262889 abstract "The effect of diphenylhydantoin (DPH) on the release of lysosomal enzymes during resorption of cultured mouse calvarial bone was studied. The enzyme activities of beta-glucuronidase and beta-galactosidase in the culture medium was taken as indicators for lysosomal enzyme release. In concentrations 50 micrograms/ml or higher, DPH inhibited the release of beta-glucuronidase and beta-galactosidase in parallel with bone resorption as indicated by reduced release of 45Ca, Ca2+, Pi and hydroxyproline. The release of the cytosolic enzyme lactate dehydrogenase was not influenced by concentrations of DPH up to 50 micrograms/ml but higher concentrations caused an increased release indicating cell injury. When bone resorption was stimulated by prostaglandin E2, DPH (50 micrograms/ml) also reduced the mobilization of bone mineral and the release of beta-glucuronidase without influencing the release of lactate dehydrogenase. It is suggested that DPH by interfering with cellular release processes reduces the resorption of bone." @default.
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- W2020262889 date "2009-03-13" @default.
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- W2020262889 title "Influence of Diphenylhydantoin on Lysosomal Enzyme Release during Bone Resorption in Vitro" @default.
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- W2020262889 doi "https://doi.org/10.1111/j.1600-0773.1980.tb01854.x" @default.
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