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• W2020265721 abstract "The neuroprotective compound, 1-aminocyclopropanecarboxylic acid (ACPC), has been reported to act on the N-methyl-D-aspartate (NMDA) receptors simultaneously as a glycine binding site agonist and a glutamate binding site competitive antagonist. The complex kinetics of NMDA current changes measured by a whole-cell voltage clamp in rat hippocampal neurons resulting from application and removal of 1 mM ACPC in the continual presence of 15 microM NMDA confirm this hypothesis. Two-electrode voltage clamp on Xenopus oocytes expressing NR1-1a and either NR2A, NR2B or NR2C subunits yielded biphasic ACPC dose response curves with 15 microM NMDA. NR1-1a/NR2B and NR1-1a/NR2C subunit combinations yielded overlapping dose response curves with a maximal efficacy of approximately 80%; the maximal efficacy of ACPC for the NR1-1a/NR2A subunit combination was significantly lower at approximately 60%." @default.
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• W2020265721 date "2002-01-01" @default.
• W2020265721 modified "2023-10-14" @default.
• W2020265721 title "Specificity of putative partial agonist, 1-aminocyclopropanecarboxylic acid, for rat N -methyl- d -aspartate receptor subunits" @default.
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• W2020265721 doi "https://doi.org/10.1016/s0304-3940(01)02430-2" @default.
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