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- W2020276794 abstract "Soft feces and a decreased delivery rate were observed in a specific-pathogen-free (SPF) C3H-scid mouse breeding colony. Grossly, the ceca were shrunken and edematous in the affected mice. Histopathologically, severe edema in the cecal submucosa as well as infiltration of inflammatory cells in the lamina propria and submucosa of the ceca and colon were observed. No pathogenic microorganisms were detected by the routine microbiological tests. By anaerobic bacterial-examination, Clostridium (C.) difficile with toxin A was isolated from the cecal contents of the affected mice. The mice were diagnosed with C. difficile-associated colitis. This case appears to be the first report of natural infection with C. difficile in SPF mice with clinical signs." @default.
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- W2020276794 date "2007-01-01" @default.
- W2020276794 modified "2023-09-26" @default.
- W2020276794 title "Colitis Associated with Clostridium difficile in Specific-Pathogen-Free C3H-scid Mice" @default.
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- W2020276794 doi "https://doi.org/10.1292/jvms.69.973" @default.
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