Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020282014> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2020282014 endingPage "1353" @default.
- W2020282014 startingPage "1345" @default.
- W2020282014 abstract "The calcium dependence of steroidogenic responses to angiotensin II, potassium, and ACTH was analyzed in isolated, adrenal glomerulosa cells incubated with inhibitors of calcium uptake. Both lanthanum and verapamil reduced the stimulation of aldosterone production by each regulator in a dose-dependent manner, with only a moderate decrease in basal steroid production. The stimulation of aldosterone and cAMP production by ACTH was blocked by both antagonists, and the degree of inhibition was dependent on the concentration of ACTH employed. Increasing concentrations of verapamil caused an increase in the ACTH concentration required for half-maximal stimulation as well as a reduction in the maximum production of aldosterone. Aldosterone production by glomerulosa cells in response to angiotensin II or potassium was also decreased by lanthanum and verapamil, with no change in the concentration of angiotensin II required for half-maximal stimulation of steroidogenesis. Stimulation of pregnenolone synthesis by angiotensin II was also inhibited by verapamil, indicating that calcium is required for the action of angiotensin II at an early step in thesteroidogenic pathway. The inhibitory action of verapamil upon angiotensin-stimulated aldosterone production was overcome by increasing concentrations of calcium. Neither of the calciumantagonists affected the binding of angiotensin II to glomerulosacells, placing the calcium requirement for the action of angiotensin II at a postreceptor locus. These results provide further evidence that angiotensin II and potassium increase aldosterone production in adrenal glomerulosa cells through a calcium-dependent mechanism, and indicate that calcium uptake is an essential requirement for the stimulation of aldosterone production by these two effectors." @default.
- W2020282014 created "2016-06-24" @default.
- W2020282014 creator A5015977609 @default.
- W2020282014 creator A5085269523 @default.
- W2020282014 date "1980-11-01" @default.
- W2020282014 modified "2023-10-15" @default.
- W2020282014 title "Dependence of Aldosterone Stimulation in Adrenal Glomerulosa Cells on Calcium Uptake: Effects of Lanthanum and Verapamil" @default.
- W2020282014 cites W1518913349 @default.
- W2020282014 cites W1549939931 @default.
- W2020282014 cites W1556936132 @default.
- W2020282014 cites W1854823303 @default.
- W2020282014 cites W1972010938 @default.
- W2020282014 cites W1978083941 @default.
- W2020282014 cites W1989468647 @default.
- W2020282014 cites W1999918819 @default.
- W2020282014 cites W2016489190 @default.
- W2020282014 cites W2026275409 @default.
- W2020282014 cites W2032883532 @default.
- W2020282014 cites W2038769354 @default.
- W2020282014 cites W2049914012 @default.
- W2020282014 cites W2073669343 @default.
- W2020282014 cites W2077673842 @default.
- W2020282014 cites W2082825600 @default.
- W2020282014 cites W2084694990 @default.
- W2020282014 cites W2087238644 @default.
- W2020282014 cites W2119216407 @default.
- W2020282014 cites W2147101763 @default.
- W2020282014 cites W2164938887 @default.
- W2020282014 cites W2167042503 @default.
- W2020282014 cites W2174751052 @default.
- W2020282014 cites W2208753097 @default.
- W2020282014 cites W2413410180 @default.
- W2020282014 cites W2413705917 @default.
- W2020282014 cites W594960487 @default.
- W2020282014 cites W83534692 @default.
- W2020282014 cites W96524793 @default.
- W2020282014 doi "https://doi.org/10.1210/endo-107-5-1345" @default.
- W2020282014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6253264" @default.
- W2020282014 hasPublicationYear "1980" @default.
- W2020282014 type Work @default.
- W2020282014 sameAs 2020282014 @default.
- W2020282014 citedByCount "166" @default.
- W2020282014 countsByYear W20202820142012 @default.
- W2020282014 countsByYear W20202820142016 @default.
- W2020282014 countsByYear W20202820142020 @default.
- W2020282014 crossrefType "journal-article" @default.
- W2020282014 hasAuthorship W2020282014A5015977609 @default.
- W2020282014 hasAuthorship W2020282014A5085269523 @default.
- W2020282014 hasConcept C104849204 @default.
- W2020282014 hasConcept C126322002 @default.
- W2020282014 hasConcept C134018914 @default.
- W2020282014 hasConcept C170493617 @default.
- W2020282014 hasConcept C185592680 @default.
- W2020282014 hasConcept C24998067 @default.
- W2020282014 hasConcept C2776069600 @default.
- W2020282014 hasConcept C2777022698 @default.
- W2020282014 hasConcept C2777977426 @default.
- W2020282014 hasConcept C2778525890 @default.
- W2020282014 hasConcept C2780178468 @default.
- W2020282014 hasConcept C2908929049 @default.
- W2020282014 hasConcept C519063684 @default.
- W2020282014 hasConcept C71924100 @default.
- W2020282014 hasConcept C86803240 @default.
- W2020282014 hasConceptScore W2020282014C104849204 @default.
- W2020282014 hasConceptScore W2020282014C126322002 @default.
- W2020282014 hasConceptScore W2020282014C134018914 @default.
- W2020282014 hasConceptScore W2020282014C170493617 @default.
- W2020282014 hasConceptScore W2020282014C185592680 @default.
- W2020282014 hasConceptScore W2020282014C24998067 @default.
- W2020282014 hasConceptScore W2020282014C2776069600 @default.
- W2020282014 hasConceptScore W2020282014C2777022698 @default.
- W2020282014 hasConceptScore W2020282014C2777977426 @default.
- W2020282014 hasConceptScore W2020282014C2778525890 @default.
- W2020282014 hasConceptScore W2020282014C2780178468 @default.
- W2020282014 hasConceptScore W2020282014C2908929049 @default.
- W2020282014 hasConceptScore W2020282014C519063684 @default.
- W2020282014 hasConceptScore W2020282014C71924100 @default.
- W2020282014 hasConceptScore W2020282014C86803240 @default.
- W2020282014 hasIssue "5" @default.
- W2020282014 hasLocation W20202820141 @default.
- W2020282014 hasLocation W20202820142 @default.
- W2020282014 hasOpenAccess W2020282014 @default.
- W2020282014 hasPrimaryLocation W20202820141 @default.
- W2020282014 hasRelatedWork W1987998575 @default.
- W2020282014 hasRelatedWork W2009549069 @default.
- W2020282014 hasRelatedWork W2010171695 @default.
- W2020282014 hasRelatedWork W2023063360 @default.
- W2020282014 hasRelatedWork W2026478029 @default.
- W2020282014 hasRelatedWork W2073103717 @default.
- W2020282014 hasRelatedWork W2141215121 @default.
- W2020282014 hasRelatedWork W2400851159 @default.
- W2020282014 hasRelatedWork W2572767566 @default.
- W2020282014 hasRelatedWork W3145681292 @default.
- W2020282014 hasVolume "107" @default.
- W2020282014 isParatext "false" @default.
- W2020282014 isRetracted "false" @default.
- W2020282014 magId "2020282014" @default.
- W2020282014 workType "article" @default.