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• W2020284906 abstract "The advent of advanced cell culture and cytogenetics techniques in the 1950s opened a new avenue for research on the pathogenic interactions between animal viruses and their hosts. Studies of many viruses revealed their ability to nonspecifically induce cytogenetic damage to their host cell's chromosomes. However, only three viruses, the oncogenic adenoviruses, herpes simplex virus (HSV) and human cytomegalovirus (HCMV), have been found to cause non-random, site-specific chromosomal damage. Adenovirus (Ad) type 12 induces fragility at four distinct loci (RNU1, RNU2, RN5S and PSU1) in many different types of human cells. A common feature of these loci is that they contain a repeated array of transcriptionally active genes encoding small structural RNAs. Site-specific induction of breaks also requires the virally encoded E1B protein of M(r) 55000 and the C-terminus of the cellular p53 protein. Analysis of the induction of damage by HSV and HCMV necessitates consideration of several factors, including the strain of virus used, the timing of infection, the type of cell used, and the multiplicity of infection. Both HSV strains 1 and 2 are cytotoxic, although the former seems to be more proficient at inducing damage. At early times post infection, HSV induces breaks and specific uncoiling of the centromeres of chromosomes 1, 9 and 16. This is followed at later times by a more complete severing of all of the chromosomes, termed pulverisation. Damage by HSV requires viral entry and de novo viral protein synthesis, with immediate early viral proteins responsible for the induction of breaks and uncoiling and early gene products (most likely nucleases) involved in the extensive pulverisation seen later. HCMV has been studied primarily in permissive human fibroblasts. Its ability to induce specific damage in chromosome 1 at two loci, 1q21 and 1q42, was only recently revealed as the cells must be in S-phase when they are infected for the breaks to be observed. In contrast to adenovirus and HSV, HCMV induction of specific breakage requires only viral entry into the cell and not de novo viral protein expression. This latter point may be a factor in its ability to cause damage in the developing fetal brain, where the most severe clinical manifestations of congenital infection are observed." @default.
• W2020284906 created "2016-06-24" @default.
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• W2020284906 date "2002-01-01" @default.
• W2020284906 modified "2023-10-01" @default.
• W2020284906 title "Viral induction of site-specific chromosome damage" @default.
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• W2020284906 cites W1776893913 @default.
• W2020284906 cites W1823872220 @default.
• W2020284906 cites W1881605486 @default.
• W2020284906 cites W1931862903 @default.
• W2020284906 cites W1967715912 @default.
• W2020284906 cites W1969793660 @default.
• W2020284906 cites W1972245437 @default.
• W2020284906 cites W1973077179 @default.
• W2020284906 cites W1973699080 @default.
• W2020284906 cites W1976246190 @default.
• W2020284906 cites W1977701495 @default.
• W2020284906 cites W1980855829 @default.
• W2020284906 cites W1983014880 @default.
• W2020284906 cites W1984201646 @default.
• W2020284906 cites W1989664952 @default.
• W2020284906 cites W2002222217 @default.
• W2020284906 cites W2002639971 @default.
• W2020284906 cites W2002853927 @default.
• W2020284906 cites W2005217723 @default.
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• W2020284906 cites W2011264220 @default.
• W2020284906 cites W2014760586 @default.
• W2020284906 cites W2016161781 @default.
• W2020284906 cites W2023158891 @default.
• W2020284906 cites W2024742568 @default.
• W2020284906 cites W2025269413 @default.
• W2020284906 cites W2032000078 @default.
• W2020284906 cites W2033643207 @default.
• W2020284906 cites W2040189419 @default.
• W2020284906 cites W2040636152 @default.
• W2020284906 cites W2041808377 @default.
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• W2020284906 cites W2059116388 @default.
• W2020284906 cites W2062093693 @default.
• W2020284906 cites W2066247917 @default.
• W2020284906 cites W2069023071 @default.
• W2020284906 cites W2071869698 @default.
• W2020284906 cites W2078911429 @default.
• W2020284906 cites W2085262691 @default.
• W2020284906 cites W2091817354 @default.
• W2020284906 cites W2093313475 @default.
• W2020284906 cites W2093600309 @default.
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• W2020284906 doi "https://doi.org/10.1002/rmv.368" @default.
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