FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020288787> ?p ?o ?g. }

• W2020288787 endingPage "5470" @default.
• W2020288787 startingPage "5458" @default.
• W2020288787 abstract "The E2F family of transcription factors are downstream effectors of the retinoblastoma protein, pRB, pathway and are essential for the timely regulation of genes necessary for cell-cycle progression. Here we describe the characterization of human and murine E2F8, a new member of the E2F family. Sequence analysis of E2F8 predicts the presence of two distinct E2F-related DNA binding domains suggesting that E2F8 and, the recently, identified E2F7 form a subgroup within the E2F family. We show that E2F transcription factors bind the E2F8 promoter in vivo and that expression of E2F8 is being induced at the G1/S transition. Purified recombinant E2F8 binds specifically to a consensus E2F-DNA-binding site indicating that E2F8, like E2F7, binds DNA without the requirement of co-factors such as DP1. E2F8 inhibits E2F-driven promoters suggesting that E2F8 is transcriptional repressor like E2F7. Ectopic expression of E2F8 in diploid human fibroblasts reduces expression of E2F-target genes and inhibits cell growth consistent with a role for repressing E2F transcriptional activity. Taken together, these data suggest that E2F8 has an important role in turning of the expression of E2F-target genes in the S-phase of the cell cycle." @default.
• W2020288787 created "2016-06-24" @default.
• W2020288787 creator A5080848888 @default.
• W2020288787 date "2005-09-25" @default.
• W2020288787 modified "2023-10-10" @default.
• W2020288787 title "Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription" @default.
• W2020288787 cites W1762601366 @default.
• W2020288787 cites W1885235228 @default.
• W2020288787 cites W1937375640 @default.
• W2020288787 cites W1978614862 @default.
• W2020288787 cites W1995979905 @default.
• W2020288787 cites W1998492363 @default.
• W2020288787 cites W2009214757 @default.
• W2020288787 cites W2021744259 @default.
• W2020288787 cites W2031203111 @default.
• W2020288787 cites W2061665609 @default.
• W2020288787 cites W2064113174 @default.
• W2020288787 cites W2065343028 @default.
• W2020288787 cites W2083187335 @default.
• W2020288787 cites W2087821827 @default.
• W2020288787 cites W2104519300 @default.
• W2020288787 cites W2122511750 @default.
• W2020288787 cites W2125378984 @default.
• W2020288787 cites W2131714689 @default.
• W2020288787 cites W2134629510 @default.
• W2020288787 cites W2140522709 @default.
• W2020288787 cites W2152264745 @default.
• W2020288787 cites W2161041571 @default.
• W2020288787 cites W2791873134 @default.
• W2020288787 cites W3026147203 @default.
• W2020288787 doi "https://doi.org/10.1093/nar/gki855" @default.
• W2020288787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1236722" @default.
• W2020288787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16179649" @default.
• W2020288787 hasPublicationYear "2005" @default.
• W2020288787 type Work @default.
• W2020288787 sameAs 2020288787 @default.
• W2020288787 citedByCount "154" @default.
• W2020288787 countsByYear W20202887872012 @default.
• W2020288787 countsByYear W20202887872013 @default.
• W2020288787 countsByYear W20202887872014 @default.
• W2020288787 countsByYear W20202887872015 @default.
• W2020288787 countsByYear W20202887872016 @default.
• W2020288787 countsByYear W20202887872017 @default.
• W2020288787 countsByYear W20202887872018 @default.
• W2020288787 countsByYear W20202887872019 @default.
• W2020288787 countsByYear W20202887872020 @default.
• W2020288787 countsByYear W20202887872021 @default.
• W2020288787 countsByYear W20202887872022 @default.
• W2020288787 countsByYear W20202887872023 @default.
• W2020288787 crossrefType "journal-article" @default.
• W2020288787 hasAuthorship W2020288787A5080848888 @default.
• W2020288787 hasBestOaLocation W20202887872 @default.
• W2020288787 hasConcept C101762097 @default.
• W2020288787 hasConcept C104317684 @default.
• W2020288787 hasConcept C138885662 @default.
• W2020288787 hasConcept C150194340 @default.
• W2020288787 hasConcept C153911025 @default.
• W2020288787 hasConcept C158448853 @default.
• W2020288787 hasConcept C179926584 @default.
• W2020288787 hasConcept C2776062698 @default.
• W2020288787 hasConcept C29537977 @default.
• W2020288787 hasConcept C41895202 @default.
• W2020288787 hasConcept C54355233 @default.
• W2020288787 hasConcept C81350143 @default.
• W2020288787 hasConcept C83258922 @default.
• W2020288787 hasConcept C86339819 @default.
• W2020288787 hasConcept C86803240 @default.
• W2020288787 hasConcept C95444343 @default.
• W2020288787 hasConcept C97037327 @default.
• W2020288787 hasConceptScore W2020288787C101762097 @default.
• W2020288787 hasConceptScore W2020288787C104317684 @default.
• W2020288787 hasConceptScore W2020288787C138885662 @default.
• W2020288787 hasConceptScore W2020288787C150194340 @default.
• W2020288787 hasConceptScore W2020288787C153911025 @default.
• W2020288787 hasConceptScore W2020288787C158448853 @default.
• W2020288787 hasConceptScore W2020288787C179926584 @default.
• W2020288787 hasConceptScore W2020288787C2776062698 @default.
• W2020288787 hasConceptScore W2020288787C29537977 @default.
• W2020288787 hasConceptScore W2020288787C41895202 @default.
• W2020288787 hasConceptScore W2020288787C54355233 @default.
• W2020288787 hasConceptScore W2020288787C81350143 @default.
• W2020288787 hasConceptScore W2020288787C83258922 @default.
• W2020288787 hasConceptScore W2020288787C86339819 @default.
• W2020288787 hasConceptScore W2020288787C86803240 @default.
• W2020288787 hasConceptScore W2020288787C95444343 @default.
• W2020288787 hasConceptScore W2020288787C97037327 @default.
• W2020288787 hasIssue "17" @default.
• W2020288787 hasLocation W20202887871 @default.
• W2020288787 hasLocation W20202887872 @default.
• W2020288787 hasLocation W20202887873 @default.
• W2020288787 hasLocation W20202887874 @default.
• W2020288787 hasLocation W20202887875 @default.
• W2020288787 hasOpenAccess W2020288787 @default.
• W2020288787 hasPrimaryLocation W20202887871 @default.
• W2020288787 hasRelatedWork W1527058604 @default.
• W2020288787 hasRelatedWork W1577460366 @default.
• W2020288787 hasRelatedWork W1947079289 @default.
• W2020288787 hasRelatedWork W1982855662 @default.

• next