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- W2020292208 abstract "<h3>To the Editor.</h3> —We have systematically evaluated prescribing errors for the past 6 years.<sup>1</sup>Recently, we have observed recurrent prescribing errors involving methotrexate for rheumatoid arthritis. Treatment with methotrexate for rheumatoid arthritis usually involves a regimen of onceweekly administration of doses ranging from 2.5 to 35 mg.2,3 Daily administration of methotrexate greatly increases the potential for toxic effects from a given dose, as it does not allow an interval for the cellular recovery from methotrexate depletion of tetrahydrofolate.<sup>4</sup>Significant toxic effects have been reported following daily administration of methotrexate (for as little as 4 days) because of medication errors.<sup>4,5</sup> In the past year we observed five patients (three inpatients and two outpatients) for whom methotrexate prescribing errors occurred. Inpatient 1 was admitted acutely for unstable angina and eventually underwent coronary bypass grafting. His preadmission medications included 7.5 mg of methotrexate once weekly. During his hospitalization, he was" @default.
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- W2020292208 date "1992-10-21" @default.
- W2020292208 modified "2023-10-14" @default.
- W2020292208 title "Errors in Prescribing Methotrexate" @default.
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- W2020292208 doi "https://doi.org/10.1001/jama.1992.03490150083021" @default.
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