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- W2020292818 abstract "Inflammation of the airways is a cardinal feature of asthma. It has recently been recognized that mast cells may contribute to this process by cytokine secretion. Activation of a number of transcription factors, such as NF-ĸB, results in the de novo synthesis of a wide spectrum of cytokines including TNFα, IL-8 and GM-CSF. We have assessed the activation of NF-ĸB by exposure of purified lung mast cells to TNFα (5 ng/ml), SCF (10 ng/ml) and anti-IgE (1 µg/ml). Mast cells were identified by cytospin immunocytochemistry using the antitryptase antibody AA-1 and activated NF-ĸB visualized by the antibody 2c7 (Upjohn) which recognizes a site revealed only on its dissociation from I-ĸB. In addition, the effects of theophylline and other modulatory drugs have been examined on NF-ĸB activation and consequential cytokine secretion. Results show that TNFα increased the percentage of cells staining positive for activated NF-ĸB from 8.4 ± 4.8 to 63 ± 4.5 within 15 min. Anti-IgE caused a slow increase from 4.3 ± 0.4 to 45.4 ± 13.3% at 4 h. Theophylline at 20 µg/ml decreased TNFα and anti-IgE induced NF-ĸB activation by 37.3 ± 2.1 and 25.3 ± 1.3%, respectively. Secretion of TNFα, IL-8 and GM-CSF was also inhibited by 20 µg/ml theophylline. The suppression of NF-ĸB activation indicates that theophylline, in addition to its bronchodilator actions, has anti-inflammatory activity which is likely to be pertinent to the treatment of bronchial asthma." @default.
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- W2020292818 date "2001-01-01" @default.
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- W2020292818 title "Theophylline at Therapeutic Concentrations Inhibits NF-κB Activation in Human Lung Mast Cells" @default.
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- W2020292818 doi "https://doi.org/10.1159/000053761" @default.
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