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• W2020295335 abstract "<i>Objective:</i> The aim of this study was to evaluate the efficacy and safety of single-agent S-1 in patients with advanced biliary tract cancer. <i>Methods:</i> S-1 was administered orally at a dose of 80 mg/m² for 28 days, followed by 14 days of rest (1 cycle); treatment was repeated until disease progression, unacceptable toxicity, or patient refusal. <i>Results:</i> Forty-five patients were enrolled between January 2005 and June 2008. Among these, 29 patients received S-1 as first-line chemotherapy and 16 patients received S-1 as second-line chemotherapy. The response rates for first- and second-line chemotherapy were 17.2 and 18.8%, respectively. The median times to progression for the first- and second-line chemotherapy groups were 4.2 and 5.5 months (p = 0.91), respectively. The median overall survival and 1-year survival rate for each group were 8.7 and 8.0 months and 42.2 and 38.2%, respectively (p = 0.62). Only the first-line chemotherapy group experienced grade 3/4 toxicities, including leukopenia (6.9%), neutropenia (10.3%), anemia (6.9%), thrombocytopenia (10.3%) and total bilirubin elevation (3.4%). <i>Conclusion:</i> S-1 monotherapy is a feasible and moderately efficacious treatment for advanced biliary tract cancer, as a first- or second-line chemotherapy regimen." @default.
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• W2020295335 date "2009-01-01" @default.
• W2020295335 modified "2023-10-01" @default.
• W2020295335 title "S-1 Monotherapy in Patients with Advanced Biliary Tract Cancer" @default.
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• W2020295335 doi "https://doi.org/10.1159/000226214" @default.
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