FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020298300> ?p ?o ?g. }

• W2020298300 endingPage "134" @default.
• W2020298300 startingPage "127" @default.
• W2020298300 abstract "Ewing sarcoma is a highly malignant tumor of bone preferentially arising in children and young adults. Its 5-year survival rate is only 50% despite the use of multimodal therapeutic approaches, requiring a search for new therapeutic targets and the development of novel therapeutic modalities. KIT and PDGFRs are type III receptor tyrosine kinases, and activating mutations in c-kit (which encodes KIT) and PDGFRs have been reported as oncogenic events in many malignancies. Imatinib is a selective inhibitor of KIT, PDGFR, and ABL tyrosine kinase activity and exerts different anti-tumor effects according to the regions of mutations in c-kit and PDGFR genes. Thus, we evaluated the immunohistochemical expression of KIT protein and the mutational status of exons 9, 11, 13, and 17 of the c-kit gene, exons 12 and 18 of the PDGFRA gene, and exon 12 of the PDGFRB gene in 71 formalin-fixed, paraffin-embedded Ewing sarcomas to increase our understanding of the potential, if any, of imatinib treatment for this malignancy. Of the 71 samples, 27 (38%) were immunohistochemically positive for KIT; however, activating mutations in c-kit were found in only 2 of 71 Ewing sarcomas (2.6%) within exon 9. No activating mutations in the PDGFRA and PDGFRB genes were found, but pleomorphism was identified in exon 18 of the PDGFRA gene. Our results for KIT protein expression agree with those of previous studies. This is the largest series of c-kit mutational analysis in Ewing sarcoma to date, and the results definitively show that c-kit activating mutations are not coincident with KIT protein expression in Ewing sarcoma in most samples. These findings imply other mechanisms for KIT activity and leave open the question of whether imatinib would be efficacious in the treatment of Ewing sarcoma." @default.
• W2020298300 created "2016-06-24" @default.
• W2020298300 creator A5002266940 @default.
• W2020298300 creator A5030329523 @default.
• W2020298300 creator A5038526789 @default.
• W2020298300 creator A5043210723 @default.
• W2020298300 creator A5054889583 @default.
• W2020298300 creator A5058694581 @default.
• W2020298300 creator A5067740377 @default.
• W2020298300 date "2007-03-01" @default.
• W2020298300 modified "2023-09-30" @default.
• W2020298300 title "Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas" @default.
• W2020298300 cites W1537640166 @default.
• W2020298300 cites W169768324 @default.
• W2020298300 cites W1752312133 @default.
• W2020298300 cites W1838055093 @default.
• W2020298300 cites W1964822816 @default.
• W2020298300 cites W1990794205 @default.
• W2020298300 cites W1991175004 @default.
• W2020298300 cites W2000551045 @default.
• W2020298300 cites W2006399108 @default.
• W2020298300 cites W2007328596 @default.
• W2020298300 cites W2016433042 @default.
• W2020298300 cites W2029919946 @default.
• W2020298300 cites W2053153412 @default.
• W2020298300 cites W2060975018 @default.
• W2020298300 cites W2067434109 @default.
• W2020298300 cites W2077632695 @default.
• W2020298300 cites W2092150176 @default.
• W2020298300 cites W2095226581 @default.
• W2020298300 cites W2101986793 @default.
• W2020298300 cites W2107813887 @default.
• W2020298300 cites W2112811492 @default.
• W2020298300 cites W2113844763 @default.
• W2020298300 cites W2125772760 @default.
• W2020298300 cites W2129767545 @default.
• W2020298300 cites W2138647235 @default.
• W2020298300 cites W2148095866 @default.
• W2020298300 cites W2151498899 @default.
• W2020298300 cites W2151900782 @default.
• W2020298300 cites W2171620774 @default.
• W2020298300 cites W2329648702 @default.
• W2020298300 doi "https://doi.org/10.1016/j.prp.2006.12.005" @default.
• W2020298300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17298867" @default.
• W2020298300 hasPublicationYear "2007" @default.
• W2020298300 type Work @default.
• W2020298300 sameAs 2020298300 @default.
• W2020298300 citedByCount "26" @default.
• W2020298300 countsByYear W20202983002012 @default.
• W2020298300 countsByYear W20202983002013 @default.
• W2020298300 countsByYear W20202983002014 @default.
• W2020298300 countsByYear W20202983002015 @default.
• W2020298300 countsByYear W20202983002016 @default.
• W2020298300 countsByYear W20202983002017 @default.
• W2020298300 countsByYear W20202983002018 @default.
• W2020298300 countsByYear W20202983002019 @default.
• W2020298300 countsByYear W20202983002020 @default.
• W2020298300 countsByYear W20202983002022 @default.
• W2020298300 countsByYear W20202983002023 @default.
• W2020298300 crossrefType "journal-article" @default.
• W2020298300 hasAuthorship W2020298300A5002266940 @default.
• W2020298300 hasAuthorship W2020298300A5030329523 @default.
• W2020298300 hasAuthorship W2020298300A5038526789 @default.
• W2020298300 hasAuthorship W2020298300A5043210723 @default.
• W2020298300 hasAuthorship W2020298300A5054889583 @default.
• W2020298300 hasAuthorship W2020298300A5058694581 @default.
• W2020298300 hasAuthorship W2020298300A5067740377 @default.
• W2020298300 hasConcept C104317684 @default.
• W2020298300 hasConcept C111829193 @default.
• W2020298300 hasConcept C121608353 @default.
• W2020298300 hasConcept C142724271 @default.
• W2020298300 hasConcept C153911025 @default.
• W2020298300 hasConcept C16930146 @default.
• W2020298300 hasConcept C170493617 @default.
• W2020298300 hasConcept C2775922572 @default.
• W2020298300 hasConcept C2777583451 @default.
• W2020298300 hasConcept C2778256501 @default.
• W2020298300 hasConcept C2778729363 @default.
• W2020298300 hasConcept C2778820342 @default.
• W2020298300 hasConcept C3019892230 @default.
• W2020298300 hasConcept C36823959 @default.
• W2020298300 hasConcept C37307934 @default.
• W2020298300 hasConcept C42362537 @default.
• W2020298300 hasConcept C502942594 @default.
• W2020298300 hasConcept C54355233 @default.
• W2020298300 hasConcept C71924100 @default.
• W2020298300 hasConcept C78221974 @default.
• W2020298300 hasConcept C86803240 @default.
• W2020298300 hasConceptScore W2020298300C104317684 @default.
• W2020298300 hasConceptScore W2020298300C111829193 @default.
• W2020298300 hasConceptScore W2020298300C121608353 @default.
• W2020298300 hasConceptScore W2020298300C142724271 @default.
• W2020298300 hasConceptScore W2020298300C153911025 @default.
• W2020298300 hasConceptScore W2020298300C16930146 @default.
• W2020298300 hasConceptScore W2020298300C170493617 @default.
• W2020298300 hasConceptScore W2020298300C2775922572 @default.
• W2020298300 hasConceptScore W2020298300C2777583451 @default.
• W2020298300 hasConceptScore W2020298300C2778256501 @default.

• next