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- W2020300272 abstract "Abstract Alterations in acetylcholinesterase (AChE) activity were investigated in middle endplate (MEP), distal endplate (DEP) and non-endplate (NEP) regions of rat diaphragm muscle after phrenic nerve transection either intrathoracically (low, 3–5 mm nerve stump) or in the neck (high, 50–55 mm nerve stump). When the phrenic nerve was severed low, the time of initial loss of AChE activity in MEP and DEP regions was 20 h. In contrast, when the nerve was transected in the neck, the onset time of AChE activity loss was delayed in both MEP and DEP regions to 24 h. Therefore, the onset time of loss of AChE activity was dependent on the nerve stump length. The rate of loss of AChE activity was not significantly different for MEP or DEP regions after either high or low nerve transection and averaged a rate of 1.54%/h. Loss of AChE activity in the NEP region was independent of nerve stump length and enzyme activity decreased at a rate of 0.62–0.63%/h, beginning immediately after nerve transection. AChE activity in phrenic nerve was also measured and was found to contribute significantly to measurements of endplate enzyme activity in diaphragm. Data indicate a nerve length-dependent loss of AChE in MEP and DEP regions of muscle with an apparent velocity of 300 mm/day, suggesting a relationship to fast axoplasmic transport of either AChE itself or a trophic factor." @default.
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- W2020300272 title "Nerve stump length-dependent loss of acetylcholinesterase activity in endplate regions of rat diaphragm" @default.
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- W2020300272 doi "https://doi.org/10.1016/0006-8993(80)91288-3" @default.
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