Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020301780> ?p ?o ?g. }
- W2020301780 endingPage "26" @default.
- W2020301780 startingPage "19" @default.
- W2020301780 abstract "Many chronic hepatitis patients with hepatitis C virus (HCV) are observed to have a degree of steatosis which is a factor in the progression of liver diseases. Transgenic mice expressing HCV core protein develop liver steatosis before the onset of hepatocellular carcinoma, suggesting active involvement of HCV in the de-regulation of lipid metabolism in host cells. However, the role of lipid metabolism in HCV life cycle has not been fully understood until the establishment of in vitro HCV infection and replication system. In this review we focus on HCV production with regard to modification of lipid metabolism observed in an in vitro HCV infection and replication system. The importance of lipid droplet to HCV production has been recognized, possibly at the stage of virus assembly, although the precise mechanism of lipid droplet for virus production remains elusive. Association of lipoprotein with HCV in circulating blood in chronic hepatitis C patients is observed. In fact, HCV released from culture medium is also associated with lipoprotein. The fact that treatment of HCV fraction with lipoprotein lipase (LPL) abolished infectivity indicates the essential role of lipoprotein's association with virus particle in the virus life cycle. In particular, apolipoprotein E (ApoE), a component of lipoprotein associated with HCV plays a pivotal role in HCV infectivity by functioning as a virus ligand to lipoprotein receptor that also functions as HCV receptor. These results strongly suggest the direct involvement of lipid metabolism in the regulation of the HCV life cycle." @default.
- W2020301780 created "2016-06-24" @default.
- W2020301780 creator A5013986009 @default.
- W2020301780 creator A5036844047 @default.
- W2020301780 creator A5040256695 @default.
- W2020301780 creator A5061519516 @default.
- W2020301780 creator A5066826502 @default.
- W2020301780 creator A5089756486 @default.
- W2020301780 date "2011-07-01" @default.
- W2020301780 modified "2023-10-17" @default.
- W2020301780 title "Lipoprotein component associated with hepatitis C virus is essential for virus infectivity" @default.
- W2020301780 cites W1973978057 @default.
- W2020301780 cites W1978649121 @default.
- W2020301780 cites W1986505810 @default.
- W2020301780 cites W1993900544 @default.
- W2020301780 cites W2003579943 @default.
- W2020301780 cites W2009664127 @default.
- W2020301780 cites W2015489330 @default.
- W2020301780 cites W2017627871 @default.
- W2020301780 cites W2022869504 @default.
- W2020301780 cites W2025270164 @default.
- W2020301780 cites W2028145691 @default.
- W2020301780 cites W2028538270 @default.
- W2020301780 cites W2029834382 @default.
- W2020301780 cites W2031602764 @default.
- W2020301780 cites W2033110360 @default.
- W2020301780 cites W2036306822 @default.
- W2020301780 cites W2042994480 @default.
- W2020301780 cites W2044193462 @default.
- W2020301780 cites W2047352444 @default.
- W2020301780 cites W2053978445 @default.
- W2020301780 cites W2054862747 @default.
- W2020301780 cites W2057967679 @default.
- W2020301780 cites W2060209229 @default.
- W2020301780 cites W2061632860 @default.
- W2020301780 cites W2075147482 @default.
- W2020301780 cites W2076955144 @default.
- W2020301780 cites W2077619079 @default.
- W2020301780 cites W2078364031 @default.
- W2020301780 cites W2084858225 @default.
- W2020301780 cites W2091925927 @default.
- W2020301780 cites W2092270878 @default.
- W2020301780 cites W2094733152 @default.
- W2020301780 cites W2094737728 @default.
- W2020301780 cites W2105291849 @default.
- W2020301780 cites W2109457390 @default.
- W2020301780 cites W2110671968 @default.
- W2020301780 cites W2118320694 @default.
- W2020301780 cites W2120165528 @default.
- W2020301780 cites W2125422148 @default.
- W2020301780 cites W2127274349 @default.
- W2020301780 cites W2131344889 @default.
- W2020301780 cites W2139731250 @default.
- W2020301780 cites W2147126871 @default.
- W2020301780 cites W2156004093 @default.
- W2020301780 cites W2160174559 @default.
- W2020301780 cites W4319308377 @default.
- W2020301780 doi "https://doi.org/10.1016/j.coviro.2011.05.017" @default.
- W2020301780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22440563" @default.
- W2020301780 hasPublicationYear "2011" @default.
- W2020301780 type Work @default.
- W2020301780 sameAs 2020301780 @default.
- W2020301780 citedByCount "26" @default.
- W2020301780 countsByYear W20203017802012 @default.
- W2020301780 countsByYear W20203017802013 @default.
- W2020301780 countsByYear W20203017802014 @default.
- W2020301780 countsByYear W20203017802015 @default.
- W2020301780 countsByYear W20203017802016 @default.
- W2020301780 countsByYear W20203017802017 @default.
- W2020301780 countsByYear W20203017802018 @default.
- W2020301780 countsByYear W20203017802019 @default.
- W2020301780 countsByYear W20203017802020 @default.
- W2020301780 crossrefType "journal-article" @default.
- W2020301780 hasAuthorship W2020301780A5013986009 @default.
- W2020301780 hasAuthorship W2020301780A5036844047 @default.
- W2020301780 hasAuthorship W2020301780A5040256695 @default.
- W2020301780 hasAuthorship W2020301780A5061519516 @default.
- W2020301780 hasAuthorship W2020301780A5066826502 @default.
- W2020301780 hasAuthorship W2020301780A5089756486 @default.
- W2020301780 hasConcept C106358424 @default.
- W2020301780 hasConcept C134018914 @default.
- W2020301780 hasConcept C140704245 @default.
- W2020301780 hasConcept C159047783 @default.
- W2020301780 hasConcept C203014093 @default.
- W2020301780 hasConcept C2522874641 @default.
- W2020301780 hasConcept C25897203 @default.
- W2020301780 hasConcept C2776175330 @default.
- W2020301780 hasConcept C2776408679 @default.
- W2020301780 hasConcept C2778163477 @default.
- W2020301780 hasConcept C2780072125 @default.
- W2020301780 hasConcept C2781463415 @default.
- W2020301780 hasConcept C4733338 @default.
- W2020301780 hasConcept C62746215 @default.
- W2020301780 hasConcept C86803240 @default.
- W2020301780 hasConceptScore W2020301780C106358424 @default.
- W2020301780 hasConceptScore W2020301780C134018914 @default.
- W2020301780 hasConceptScore W2020301780C140704245 @default.
- W2020301780 hasConceptScore W2020301780C159047783 @default.