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- W2020304838 abstract "<h2>Abstract</h2> A direct correlation between the elevation of blood levels of corticosteroids and the increase in the metabolism of corticosteroids by the liver was observed in vitro and in vivo. The mechanism of this auto-regulatory system of corticosteroid metabolism by the liver, secondary to fluctuation of their blood levels, was studied. The rate of corticosteroid metabolism in the liver was greater at higher levels of nonprotein-bound corticosteroids in serum than that obtained at lower levels. This suggests an important role of the activity of steroid hydrogenases in this regulatory system. In addition, the serum protein binding of corticosteroids plays a role in this regulatory system. The nonprotein-bound corticosteroids in serum were more rapidly metabolized in the liver than the protein-bound corticosteroids. Under the physiologic conditions where the total steroid level in serum was below the binding capacity of serum protein, at lower corticosteroid levels a proportionally greater amount of corticosteroids in the blood was bound to serum protein, and relatively less available to the liver for metabolism than would obtain at higher corticosteroid levels. Thus, the serum protein binding of corticosteroids plays a role in the regulation of corticosteroid metabolism in the liver. An autoregulatory system of corticosteroid metabolism in the liver plays a role in controlling the concentration of blood corticosteroids supplementary to the control by the regulation of adrenal cortical secretion." @default.
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- W2020304838 title "Study of mechanism of autoregulatory system of corticosteroid metabolism in liver" @default.
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- W2020304838 doi "https://doi.org/10.1016/0026-0495(72)90022-4" @default.
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