Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020305110> ?p ?o ?g. }
- W2020305110 endingPage "115" @default.
- W2020305110 startingPage "101" @default.
- W2020305110 abstract "Abstract Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and non-cell-autonomous growth control roles of NS3 in Drosophila and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, demonstrate the necessity of NS3 for cell autonomous growth. A hypomorphic allele highlights the hypersensitivity of neurons to lowered NS3 function. We propose that NS3 is the functional ortholog of yeast and human Lsg1, which promotes release of the nuclear export adapter from the large ribosomal subunit. Release of the adapter and its recycling to the nucleus are essential for sustained production of ribosomes. The ribosome biogenesis role of NS3 is essential for proper rates of translation in all tissues and is necessary for functions of growth-promoting neurons." @default.
- W2020305110 created "2016-06-24" @default.
- W2020305110 creator A5018795749 @default.
- W2020305110 creator A5021011160 @default.
- W2020305110 creator A5023042103 @default.
- W2020305110 creator A5028232612 @default.
- W2020305110 creator A5043044406 @default.
- W2020305110 creator A5043238367 @default.
- W2020305110 creator A5051035165 @default.
- W2020305110 creator A5059129180 @default.
- W2020305110 creator A5062842496 @default.
- W2020305110 creator A5073037820 @default.
- W2020305110 creator A5077928578 @default.
- W2020305110 creator A5083874290 @default.
- W2020305110 date "2013-05-01" @default.
- W2020305110 modified "2023-09-26" @default.
- W2020305110 title "Regulation of Ribosome Biogenesis by Nucleostemin 3 Promotes Local and Systemic Growth in <i>Drosophila</i>" @default.
- W2020305110 cites W1554952163 @default.
- W2020305110 cites W1559258852 @default.
- W2020305110 cites W1966813038 @default.
- W2020305110 cites W1966901093 @default.
- W2020305110 cites W1975749924 @default.
- W2020305110 cites W1978921497 @default.
- W2020305110 cites W1981715749 @default.
- W2020305110 cites W1984789478 @default.
- W2020305110 cites W1985744441 @default.
- W2020305110 cites W1986158689 @default.
- W2020305110 cites W1987942547 @default.
- W2020305110 cites W1989177998 @default.
- W2020305110 cites W1991156150 @default.
- W2020305110 cites W1992031613 @default.
- W2020305110 cites W1993247470 @default.
- W2020305110 cites W1996923021 @default.
- W2020305110 cites W1999075942 @default.
- W2020305110 cites W2002462699 @default.
- W2020305110 cites W2018305417 @default.
- W2020305110 cites W2022076650 @default.
- W2020305110 cites W2022954501 @default.
- W2020305110 cites W2022984307 @default.
- W2020305110 cites W2026249269 @default.
- W2020305110 cites W2037055277 @default.
- W2020305110 cites W2037366394 @default.
- W2020305110 cites W2042573239 @default.
- W2020305110 cites W2047024375 @default.
- W2020305110 cites W2049936165 @default.
- W2020305110 cites W2056032938 @default.
- W2020305110 cites W2060968828 @default.
- W2020305110 cites W2063908091 @default.
- W2020305110 cites W2067826995 @default.
- W2020305110 cites W2069942503 @default.
- W2020305110 cites W2077167882 @default.
- W2020305110 cites W2086750718 @default.
- W2020305110 cites W2087555780 @default.
- W2020305110 cites W2088553830 @default.
- W2020305110 cites W2088599563 @default.
- W2020305110 cites W2089667459 @default.
- W2020305110 cites W2093468914 @default.
- W2020305110 cites W2094874234 @default.
- W2020305110 cites W2095625368 @default.
- W2020305110 cites W2095628760 @default.
- W2020305110 cites W2096126612 @default.
- W2020305110 cites W2099540110 @default.
- W2020305110 cites W2099996820 @default.
- W2020305110 cites W2114332413 @default.
- W2020305110 cites W2119515698 @default.
- W2020305110 cites W2119965520 @default.
- W2020305110 cites W2124060308 @default.
- W2020305110 cites W2124693268 @default.
- W2020305110 cites W2126431396 @default.
- W2020305110 cites W2137015675 @default.
- W2020305110 cites W2138505246 @default.
- W2020305110 cites W2152038133 @default.
- W2020305110 cites W2152561142 @default.
- W2020305110 cites W2157934217 @default.
- W2020305110 cites W2161201097 @default.
- W2020305110 cites W2165921475 @default.
- W2020305110 cites W2166863403 @default.
- W2020305110 cites W2170736126 @default.
- W2020305110 cites W2171323620 @default.
- W2020305110 cites W4238839969 @default.
- W2020305110 doi "https://doi.org/10.1534/genetics.112.149104" @default.
- W2020305110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3632458" @default.
- W2020305110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23436180" @default.
- W2020305110 hasPublicationYear "2013" @default.
- W2020305110 type Work @default.
- W2020305110 sameAs 2020305110 @default.
- W2020305110 citedByCount "10" @default.
- W2020305110 countsByYear W20203051102014 @default.
- W2020305110 countsByYear W20203051102015 @default.
- W2020305110 countsByYear W20203051102016 @default.
- W2020305110 countsByYear W20203051102017 @default.
- W2020305110 countsByYear W20203051102018 @default.
- W2020305110 countsByYear W20203051102019 @default.
- W2020305110 countsByYear W20203051102020 @default.
- W2020305110 countsByYear W20203051102022 @default.
- W2020305110 crossrefType "journal-article" @default.
- W2020305110 hasAuthorship W2020305110A5018795749 @default.
- W2020305110 hasAuthorship W2020305110A5021011160 @default.