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- W2020308127 abstract "Among the methods of biological dosimetry of ionizing radiation, we propose the cytokinesis-block micronucleus assay for the measurement of the individual dose absorbed. The dose-response curve was determined for in vitro-irradiated lymphocytes from 25 individuals. The dose-response relationship, fitted by the linear-quadratic function, was F(MN) = 0.015 (+/- 0.0016) + 0.043 (+/- 0.0075).D + 0.083 (+/- 0.0045).D2. Our results are compared with those of other authors. 3-aminobenzamide (3AB) combined with X-rays were used to evaluate the micronucleus dose-response relationship in blood from 14 individuals. While it is known that 3AB inhibits poly(ADP-ribose) polymerase activity in vitro, we demonstrate that it also increases the X-ray-induced micronucleus yields. The resulting dose-response relationship varies from subject to subject. The possibility of using this approach to identify the individual radiosensitivity level is discussed." @default.
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- W2020308127 date "1992-01-01" @default.
- W2020308127 modified "2023-09-25" @default.
- W2020308127 title "Inter-individual Differences in Radiation Respone Shown by anin VitroMicronucleus Assay: Effects of 3-aminobenzamide on X-ray Treatment" @default.
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- W2020308127 doi "https://doi.org/10.1080/09553009214552641" @default.
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