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- W2020308275 endingPage "643" @default.
- W2020308275 startingPage "631" @default.
- W2020308275 abstract "Beta-2-Adrenergic receptors (β2AR) participate in the physiologic responses of the lung, including bronchodilation and bronchoprotection, through mechanisms such as mucociliary clearance, fluid accumulation and mediator release from mast cells and basophils. Thus, these receptors may also play an important role in the pathophysiology of asthma. The gene encoding β2AR (ADRB2) is extremely polymorphic, and studies of this gene improves our understanding of asthma and possibly lead to new methods to prevent, diagnose and treat it. This review summarizes results from various studies on the possible relationship of ADRB2 polymorphisms to asthma and asthma-related phenotypes, including bronchodilator responses to inhaled β2-agonists. At present, it appears that, for asthma, ADRB2 polymorphisms are not aetiologically involved. However, they might affect disease severity and clinical response to both acute and chronic administration of β2-agonists. The development is that by assessing the ADRB2 genotype, it might be possible to predict the clinical course of asthma as well as responsiveness to chronic administration of β2-agonists. Carefully, performed and adequately powered clinical trials continue to be important for achieving those goals." @default.
- W2020308275 created "2016-06-24" @default.
- W2020308275 creator A5014676549 @default.
- W2020308275 date "2009-12-01" @default.
- W2020308275 modified "2023-09-25" @default.
- W2020308275 title "Beta-2 adrenergic receptor genetic polymorphisms and asthma" @default.
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