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• W2020309065 abstract "The present study investigated the possible protective role of Withania somnifera (Linn.) Dunal (Solanaceae) root powder against bromobenzene-induced oxidative damage in rat liver mitochondria. Administration of bromobenzene (10 mmol/kg body weight) to rats resulted in increased levels of liver marker enzymes, lipid peroxidation, TNF-α, IL-1β and VEGF. There was also marked depletion in the levels of mitochondrial enzymes and antioxidant activity. Pre-treatment with W. somnifera significantly decreased the levels of liver marker enzymes, TNF-α, IL-1β, VEGF and ameliorated histopathological manifestations in bromobenzene-treated rats. The molecular docking analysis predicted that the pro-inflammatory mediator NF-κB showed significant interaction with selected various active components of W. somnifera (withaferin A, withanolide D and withanolide E). This study demonstrates a good protective effect of W. somnifera against bromobenzene-induced oxidative stress." @default.
• W2020309065 created "2016-06-24" @default.
• W2020309065 creator A5006573609 @default.
• W2020309065 creator A5018744053 @default.
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• W2020309065 date "2014-01-01" @default.
• W2020309065 modified "2023-10-03" @default.
• W2020309065 title "Amelioration of bromobenzene hepatotoxicity by Withania somnifera pretreatment: Role of mitochondrial oxidative stress" @default.
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• W2020309065 doi "https://doi.org/10.1016/j.toxrep.2014.08.009" @default.
• W2020309065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5598216" @default.
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