FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020315021> ?p ?o ?g. }

• W2020315021 endingPage "162" @default.
• W2020315021 startingPage "156" @default.
• W2020315021 abstract "Absorption enhancing effects of chitosan oligomers with different type and varying concentration on the intestinal absorption of low molecular weight heparin (LMWH) were examined by an in situ closed loop method in different intestinal sections of rats. Chitosan hexamer with the optimal concentration of 0.5% (w/v) showed the highest absorption enhancing ability both in the small intestine and large intestine. The membrane toxicities of chitosan oligomers were evaluated by morphological observation and determining the biological markers including amount of protein and activity of lactate dehydrogenase (LDH) released from intestinal epithelium cells. There was no obvious change both in levels of protein and LDH and morphology in the intestinal membrane between control and various chitosan oligomers groups, suggesting that chitosan oligomers did not induce any significant membrane damage to the intestinal epithelium. In addition, zeta potentials became less negative and amount of free LMWH gradually decreased when various chitosan oligomers were added to LMWH solution, revealing that electrostatic interaction between positively charged chitosan oligomers and negative LMWH was included in the absorption enhancing mechanism of chitosan oligomers. In conclusion, chitosan oligomers, especially chitosan hexamer, are safe and efficient absorption enhancers and can be used promisingly to improve oral absorption of LMWH." @default.
• W2020315021 created "2016-06-24" @default.
• W2020315021 creator A5022610725 @default.
• W2020315021 creator A5027072664 @default.
• W2020315021 creator A5036909733 @default.
• W2020315021 creator A5046510313 @default.
• W2020315021 creator A5050088429 @default.
• W2020315021 creator A5060619493 @default.
• W2020315021 creator A5087308491 @default.
• W2020315021 date "2014-05-01" @default.
• W2020315021 modified "2023-10-14" @default.
• W2020315021 title "Absorption enhancing effects of chitosan oligomers on the intestinal absorption of low molecular weight heparin in rats" @default.
• W2020315021 cites W133642852 @default.
• W2020315021 cites W1966611441 @default.
• W2020315021 cites W1971459340 @default.
• W2020315021 cites W1975230408 @default.
• W2020315021 cites W1976301609 @default.
• W2020315021 cites W1984256156 @default.
• W2020315021 cites W1986549960 @default.
• W2020315021 cites W1998551278 @default.
• W2020315021 cites W2004735852 @default.
• W2020315021 cites W2006334961 @default.
• W2020315021 cites W2013399032 @default.
• W2020315021 cites W2016547867 @default.
• W2020315021 cites W2022228095 @default.
• W2020315021 cites W2031185644 @default.
• W2020315021 cites W2041240538 @default.
• W2020315021 cites W2043483820 @default.
• W2020315021 cites W2052157194 @default.
• W2020315021 cites W2062853793 @default.
• W2020315021 cites W2063207586 @default.
• W2020315021 cites W2063584869 @default.
• W2020315021 cites W2066087069 @default.
• W2020315021 cites W2066172109 @default.
• W2020315021 cites W2068575176 @default.
• W2020315021 cites W2069217160 @default.
• W2020315021 cites W2073575392 @default.
• W2020315021 cites W2075738307 @default.
• W2020315021 cites W2075761601 @default.
• W2020315021 cites W2077966308 @default.
• W2020315021 cites W2087421919 @default.
• W2020315021 cites W2090674210 @default.
• W2020315021 cites W2139863135 @default.
• W2020315021 cites W2155765583 @default.
• W2020315021 cites W2335162425 @default.
• W2020315021 cites W2471797427 @default.
• W2020315021 cites W82834432 @default.
• W2020315021 doi "https://doi.org/10.1016/j.ijpharm.2014.03.010" @default.
• W2020315021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24614577" @default.
• W2020315021 hasPublicationYear "2014" @default.
• W2020315021 type Work @default.
• W2020315021 sameAs 2020315021 @default.
• W2020315021 citedByCount "18" @default.
• W2020315021 countsByYear W20203150212015 @default.
• W2020315021 countsByYear W20203150212016 @default.
• W2020315021 countsByYear W20203150212017 @default.
• W2020315021 countsByYear W20203150212018 @default.
• W2020315021 countsByYear W20203150212019 @default.
• W2020315021 countsByYear W20203150212020 @default.
• W2020315021 countsByYear W20203150212021 @default.
• W2020315021 countsByYear W20203150212022 @default.
• W2020315021 countsByYear W20203150212023 @default.
• W2020315021 crossrefType "journal-article" @default.
• W2020315021 hasAuthorship W2020315021A5022610725 @default.
• W2020315021 hasAuthorship W2020315021A5027072664 @default.
• W2020315021 hasAuthorship W2020315021A5036909733 @default.
• W2020315021 hasAuthorship W2020315021A5046510313 @default.
• W2020315021 hasAuthorship W2020315021A5050088429 @default.
• W2020315021 hasAuthorship W2020315021A5060619493 @default.
• W2020315021 hasAuthorship W2020315021A5087308491 @default.
• W2020315021 hasConcept C125287762 @default.
• W2020315021 hasConcept C12554922 @default.
• W2020315021 hasConcept C155672457 @default.
• W2020315021 hasConcept C159985019 @default.
• W2020315021 hasConcept C171250308 @default.
• W2020315021 hasConcept C185592680 @default.
• W2020315021 hasConcept C189754071 @default.
• W2020315021 hasConcept C192562407 @default.
• W2020315021 hasConcept C2779732960 @default.
• W2020315021 hasConcept C2781077229 @default.
• W2020315021 hasConcept C41625074 @default.
• W2020315021 hasConcept C529295009 @default.
• W2020315021 hasConcept C54355233 @default.
• W2020315021 hasConcept C55493867 @default.
• W2020315021 hasConcept C86181022 @default.
• W2020315021 hasConcept C86803240 @default.
• W2020315021 hasConceptScore W2020315021C125287762 @default.
• W2020315021 hasConceptScore W2020315021C12554922 @default.
• W2020315021 hasConceptScore W2020315021C155672457 @default.
• W2020315021 hasConceptScore W2020315021C159985019 @default.
• W2020315021 hasConceptScore W2020315021C171250308 @default.
• W2020315021 hasConceptScore W2020315021C185592680 @default.
• W2020315021 hasConceptScore W2020315021C189754071 @default.
• W2020315021 hasConceptScore W2020315021C192562407 @default.
• W2020315021 hasConceptScore W2020315021C2779732960 @default.
• W2020315021 hasConceptScore W2020315021C2781077229 @default.
• W2020315021 hasConceptScore W2020315021C41625074 @default.
• W2020315021 hasConceptScore W2020315021C529295009 @default.

• next