FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020320512> ?p ?o ?g. }

• W2020320512 endingPage "1717" @default.
• W2020320512 startingPage "1710" @default.
• W2020320512 abstract "Vascular endothelial growth factor (VEGF) is the predominant pro-angiogenic cytokine in human malignancy, and its expression correlates with disease recurrence and poor outcomes in patients with colorectal cancer. Recently, expression of vascular endothelial growth factor receptors (VEGFRs) has been observed on tumours of epithelial origin, including those arising in the colon, but the molecular mechanisms governing potential VEGF-driven biologic functioning in these tumours are not well characterised. In this report, we investigated the role of Src family kinases (SFKs) in VEGF-mediated signalling in human colorectal carcinoma (CRC) cell lines. Vascular endothelial growth factor specifically activated SFKs in HT29 and KM12L4 CRC cell lines. Further, VEGF stimulation resulted in enhanced cellular migration, which was effectively blocked by pharmacologic inhibition of VEGFR-1 or Src kinase. Correspondingly, migration studies using siRNA clones with reduced Src expression confirmed the requirement for Src in VEGF-induced migration in these cells. Furthermore, VEGF treatment enhanced VEGFR-1/SFK complex formation and increased tyrosine phosphorylation of focal adhesion kinase, p130 cas and paxillin. Finally, we demonstrate that VEGF-induced migration is not due, at least in part, to VEGF acting as a mitogen. These results suggest that VEGFR-1 promotes migration of tumour cells through a Src-dependent pathway linked to activation of focal adhesion components that regulate this process." @default.
• W2020320512 created "2016-06-24" @default.
• W2020320512 creator A5026920212 @default.
• W2020320512 creator A5028196907 @default.
• W2020320512 creator A5034470719 @default.
• W2020320512 creator A5038143218 @default.
• W2020320512 creator A5042341684 @default.
• W2020320512 creator A5045986671 @default.
• W2020320512 creator A5061333993 @default.
• W2020320512 creator A5067465729 @default.
• W2020320512 creator A5074599944 @default.
• W2020320512 creator A5082655309 @default.
• W2020320512 creator A5090144335 @default.
• W2020320512 date "2006-05-09" @default.
• W2020320512 modified "2023-10-09" @default.
• W2020320512 title "Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases" @default.
• W2020320512 cites W1532635242 @default.
• W2020320512 cites W1589166971 @default.
• W2020320512 cites W1600542667 @default.
• W2020320512 cites W1772825397 @default.
• W2020320512 cites W1863396779 @default.
• W2020320512 cites W1875554126 @default.
• W2020320512 cites W1913527145 @default.
• W2020320512 cites W1968306692 @default.
• W2020320512 cites W1978165300 @default.
• W2020320512 cites W1983763042 @default.
• W2020320512 cites W1996537616 @default.
• W2020320512 cites W2001102844 @default.
• W2020320512 cites W2001672029 @default.
• W2020320512 cites W2003598961 @default.
• W2020320512 cites W2009081283 @default.
• W2020320512 cites W2015867957 @default.
• W2020320512 cites W2030565228 @default.
• W2020320512 cites W2031678752 @default.
• W2020320512 cites W2040972148 @default.
• W2020320512 cites W2047765160 @default.
• W2020320512 cites W2051535010 @default.
• W2020320512 cites W2054050668 @default.
• W2020320512 cites W2057965634 @default.
• W2020320512 cites W2063787079 @default.
• W2020320512 cites W2064106922 @default.
• W2020320512 cites W2084947524 @default.
• W2020320512 cites W2101257013 @default.
• W2020320512 cites W2110630778 @default.
• W2020320512 cites W2116936948 @default.
• W2020320512 cites W2117834514 @default.
• W2020320512 cites W2121881330 @default.
• W2020320512 cites W2122844152 @default.
• W2020320512 cites W2141046053 @default.
• W2020320512 cites W2146578030 @default.
• W2020320512 cites W2146802621 @default.
• W2020320512 cites W2148763134 @default.
• W2020320512 cites W2157769714 @default.
• W2020320512 cites W2166156136 @default.
• W2020320512 cites W2170201138 @default.
• W2020320512 cites W2183169576 @default.
• W2020320512 cites W2229800306 @default.
• W2020320512 cites W2330746655 @default.
• W2020320512 cites W4242182325 @default.
• W2020320512 cites W4376043839 @default.
• W2020320512 doi "https://doi.org/10.1038/sj.bjc.6603143" @default.
• W2020320512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2361330" @default.
• W2020320512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16685275" @default.
• W2020320512 hasPublicationYear "2006" @default.
• W2020320512 type Work @default.
• W2020320512 sameAs 2020320512 @default.
• W2020320512 citedByCount "116" @default.
• W2020320512 countsByYear W20203205122012 @default.
• W2020320512 countsByYear W20203205122013 @default.
• W2020320512 countsByYear W20203205122014 @default.
• W2020320512 countsByYear W20203205122015 @default.
• W2020320512 countsByYear W20203205122016 @default.
• W2020320512 countsByYear W20203205122017 @default.
• W2020320512 countsByYear W20203205122018 @default.
• W2020320512 countsByYear W20203205122019 @default.
• W2020320512 countsByYear W20203205122020 @default.
• W2020320512 countsByYear W20203205122021 @default.
• W2020320512 countsByYear W20203205122022 @default.
• W2020320512 countsByYear W20203205122023 @default.
• W2020320512 crossrefType "journal-article" @default.
• W2020320512 hasAuthorship W2020320512A5026920212 @default.
• W2020320512 hasAuthorship W2020320512A5028196907 @default.
• W2020320512 hasAuthorship W2020320512A5034470719 @default.
• W2020320512 hasAuthorship W2020320512A5038143218 @default.
• W2020320512 hasAuthorship W2020320512A5042341684 @default.
• W2020320512 hasAuthorship W2020320512A5045986671 @default.
• W2020320512 hasAuthorship W2020320512A5061333993 @default.
• W2020320512 hasAuthorship W2020320512A5067465729 @default.
• W2020320512 hasAuthorship W2020320512A5074599944 @default.
• W2020320512 hasAuthorship W2020320512A5082655309 @default.
• W2020320512 hasAuthorship W2020320512A5090144335 @default.
• W2020320512 hasBestOaLocation W20203205121 @default.
• W2020320512 hasConcept C103041312 @default.
• W2020320512 hasConcept C108636557 @default.
• W2020320512 hasConcept C116581196 @default.
• W2020320512 hasConcept C137738243 @default.
• W2020320512 hasConcept C146285616 @default.
• W2020320512 hasConcept C14858245 @default.

• next