FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020338889> ?p ?o ?g. }

• W2020338889 endingPage "7930" @default.
• W2020338889 startingPage "7926" @default.
• W2020338889 abstract "Nitric oxide synthesized by inducible nitric oxide synthase (iNOS) has been implicated as a mediator of inflammation in rheumatic and autoimmune diseases. We report that exposure of lipopolysaccharide-stimulated murine macrophages to therapeutic concentrations of aspirin (IC50 = 3 mM) and hydrocortisone (IC50 = 5 microM) inhibited the expression of iNOS and production of nitrite. In contrast, sodium salicylate (1-3 mM), indomethacin (5-20 microM), and acetaminophen (60-120 microM) had no significant effect on the production of nitrite at pharmacological concentrations. At suprapharmacological concentrations, sodium salicylate (IC50 = 20 mM) significantly inhibited nitrite production. Immunoblot analysis of iNOS expression in the presence of aspirin showed inhibition of iNOS expression (IC50 = 3 mM). Sodium salicylate variably inhibited iNOS expression (0-35%), whereas indomethacin had no effect. Furthermore, there was no significant effect of these nonsteroidal anti-inflammatory drugs on iNOS mRNA expression at pharmacological concentrations. The effect of aspirin was not due to inhibition of cyclooxygenase 2 because both aspirin and indomethacin inhibited prostaglandin E2 synthesis by > 75%. Aspirin and N-acetylimidazole (an effective acetylating agent), but not sodium salicylate or indomethacin, also directly interfered with the catalytic activity of iNOS in cell-free extracts. These studies indicate that the inhibition of iNOS expression and function represents another mechanism of action for aspirin, if not for all aspirin-like drugs. The effects are exerted at the level of translational/posttranslational modification and directly on the catalytic activity of iNOS." @default.
• W2020338889 created "2016-06-24" @default.
• W2020338889 creator A5003861776 @default.
• W2020338889 creator A5009880397 @default.
• W2020338889 creator A5010891050 @default.
• W2020338889 creator A5030914641 @default.
• W2020338889 creator A5031758172 @default.
• W2020338889 creator A5054408146 @default.
• W2020338889 creator A5084425012 @default.
• W2020338889 date "1995-08-15" @default.
• W2020338889 modified "2023-09-26" @default.
• W2020338889 title "The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase." @default.
• W2020338889 cites W1591881963 @default.
• W2020338889 cites W1660326086 @default.
• W2020338889 cites W1674582945 @default.
• W2020338889 cites W1965077361 @default.
• W2020338889 cites W1973018387 @default.
• W2020338889 cites W1977125253 @default.
• W2020338889 cites W1982515380 @default.
• W2020338889 cites W1985839335 @default.
• W2020338889 cites W2007737411 @default.
• W2020338889 cites W2010018399 @default.
• W2020338889 cites W2010237936 @default.
• W2020338889 cites W2012810767 @default.
• W2020338889 cites W2013023382 @default.
• W2020338889 cites W2033496106 @default.
• W2020338889 cites W2045846314 @default.
• W2020338889 cites W2046882461 @default.
• W2020338889 cites W2048152958 @default.
• W2020338889 cites W2054821014 @default.
• W2020338889 cites W2069594598 @default.
• W2020338889 cites W2072349322 @default.
• W2020338889 cites W2074627693 @default.
• W2020338889 cites W2085373839 @default.
• W2020338889 cites W2089747387 @default.
• W2020338889 cites W2113580903 @default.
• W2020338889 cites W2158686638 @default.
• W2020338889 cites W2576734941 @default.
• W2020338889 cites W4232534952 @default.
• W2020338889 doi "https://doi.org/10.1073/pnas.92.17.7926" @default.
• W2020338889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/41259" @default.
• W2020338889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7544010" @default.
• W2020338889 hasPublicationYear "1995" @default.
• W2020338889 type Work @default.
• W2020338889 sameAs 2020338889 @default.
• W2020338889 citedByCount "283" @default.
• W2020338889 countsByYear W20203388892012 @default.
• W2020338889 countsByYear W20203388892013 @default.
• W2020338889 countsByYear W20203388892014 @default.
• W2020338889 countsByYear W20203388892015 @default.
• W2020338889 countsByYear W20203388892016 @default.
• W2020338889 countsByYear W20203388892017 @default.
• W2020338889 countsByYear W20203388892018 @default.
• W2020338889 countsByYear W20203388892019 @default.
• W2020338889 countsByYear W20203388892020 @default.
• W2020338889 countsByYear W20203388892021 @default.
• W2020338889 countsByYear W20203388892022 @default.
• W2020338889 countsByYear W20203388892023 @default.
• W2020338889 crossrefType "journal-article" @default.
• W2020338889 hasAuthorship W2020338889A5003861776 @default.
• W2020338889 hasAuthorship W2020338889A5009880397 @default.
• W2020338889 hasAuthorship W2020338889A5010891050 @default.
• W2020338889 hasAuthorship W2020338889A5030914641 @default.
• W2020338889 hasAuthorship W2020338889A5031758172 @default.
• W2020338889 hasAuthorship W2020338889A5054408146 @default.
• W2020338889 hasAuthorship W2020338889A5084425012 @default.
• W2020338889 hasBestOaLocation W20203388891 @default.
• W2020338889 hasConcept C134018914 @default.
• W2020338889 hasConcept C178790620 @default.
• W2020338889 hasConcept C181199279 @default.
• W2020338889 hasConcept C185592680 @default.
• W2020338889 hasConcept C202751555 @default.
• W2020338889 hasConcept C2777622882 @default.
• W2020338889 hasConcept C2777628954 @default.
• W2020338889 hasConcept C2777752497 @default.
• W2020338889 hasConcept C2778754761 @default.
• W2020338889 hasConcept C2779134981 @default.
• W2020338889 hasConcept C2779689624 @default.
• W2020338889 hasConcept C519581460 @default.
• W2020338889 hasConcept C55493867 @default.
• W2020338889 hasConcept C71924100 @default.
• W2020338889 hasConcept C98274493 @default.
• W2020338889 hasConceptScore W2020338889C134018914 @default.
• W2020338889 hasConceptScore W2020338889C178790620 @default.
• W2020338889 hasConceptScore W2020338889C181199279 @default.
• W2020338889 hasConceptScore W2020338889C185592680 @default.
• W2020338889 hasConceptScore W2020338889C202751555 @default.
• W2020338889 hasConceptScore W2020338889C2777622882 @default.
• W2020338889 hasConceptScore W2020338889C2777628954 @default.
• W2020338889 hasConceptScore W2020338889C2777752497 @default.
• W2020338889 hasConceptScore W2020338889C2778754761 @default.
• W2020338889 hasConceptScore W2020338889C2779134981 @default.
• W2020338889 hasConceptScore W2020338889C2779689624 @default.
• W2020338889 hasConceptScore W2020338889C519581460 @default.
• W2020338889 hasConceptScore W2020338889C55493867 @default.
• W2020338889 hasConceptScore W2020338889C71924100 @default.
• W2020338889 hasConceptScore W2020338889C98274493 @default.
• W2020338889 hasIssue "17" @default.

• next