FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020343457> ?p ?o ?g. }

• W2020343457 endingPage "e56790" @default.
• W2020343457 startingPage "e56790" @default.
• W2020343457 abstract "Bone morphogenetic proteins (BMPs) are recognized for their ability to induce bone formation in vivo and in vitro. Their osteogenic and osteoinductive properties are tightly regulated by the secretion of specific BMP antagonists, which have been shown to physically bind and sometimes be blocked by the extracellular proteoglycan heparan sulphate side chains (from hereon referred to as HS). The purpose of this study was to investigate if local application of 5 µg of HS proteoglycan to a bone regenerate site in a mouse model of distraction osteogenesis (DO) can accelerate bone healing and affect the expression of key members of the BMP signaling pathway. DO was performed on the right tibia of 115 adult male wild-type mice. At mid-distraction (day 11), half the group was injected locally with 5 µg of HS, while the other half was injected with saline. The mice were sacrificed at 2 time-points: mid-consolidation (34 days) and full consolidation (51 days). The distracted tibial zone was then collected for analysis by μCT, radiology, biomechanical testing, immunohistochemistry, and histology. While μCT data showed no statistically significant difference in bone formation, the results of biomechanical testing in stiffness and ultimate force were significantly lower in the HS-injected bones at 51 days, compared to controls. Immunohistochemistry results also suggested a decrease in expression of several key members of the BMP signaling pathway at 34 days. Furthermore, wound dehiscence and infection rates were significantly elevated in the HS group compared to the controls, which resulted in a higher rate of euthanasia in the treatment group. Our findings demonstrate that exogenous application of 5 µg of HS in the distracted gap of a murine model had a negative impact on bone and wound healing." @default.
• W2020343457 created "2016-06-24" @default.
• W2020343457 creator A5034693624 @default.
• W2020343457 creator A5052739966 @default.
• W2020343457 creator A5076289593 @default.
• W2020343457 creator A5082900373 @default.
• W2020343457 creator A5083217078 @default.
• W2020343457 creator A5091418914 @default.
• W2020343457 date "2013-02-15" @default.
• W2020343457 modified "2023-10-01" @default.
• W2020343457 title "The Effect of Heparan Sulfate Application on Bone Formation during Distraction Osteogenesis" @default.
• W2020343457 cites W1967730199 @default.
• W2020343457 cites W1973428054 @default.
• W2020343457 cites W1974873948 @default.
• W2020343457 cites W1978974209 @default.
• W2020343457 cites W1986860803 @default.
• W2020343457 cites W1993817188 @default.
• W2020343457 cites W1995249521 @default.
• W2020343457 cites W1998650790 @default.
• W2020343457 cites W2013011415 @default.
• W2020343457 cites W2015574865 @default.
• W2020343457 cites W2016007793 @default.
• W2020343457 cites W2016023813 @default.
• W2020343457 cites W2025956923 @default.
• W2020343457 cites W2029796183 @default.
• W2020343457 cites W2031911556 @default.
• W2020343457 cites W2036469214 @default.
• W2020343457 cites W2037512521 @default.
• W2020343457 cites W2040790809 @default.
• W2020343457 cites W2040924403 @default.
• W2020343457 cites W2041703901 @default.
• W2020343457 cites W2053362631 @default.
• W2020343457 cites W2053394436 @default.
• W2020343457 cites W2057364465 @default.
• W2020343457 cites W2061419466 @default.
• W2020343457 cites W2063549145 @default.
• W2020343457 cites W2066260122 @default.
• W2020343457 cites W2067823464 @default.
• W2020343457 cites W2071228089 @default.
• W2020343457 cites W2073378176 @default.
• W2020343457 cites W2085644952 @default.
• W2020343457 cites W2086431090 @default.
• W2020343457 cites W2089234611 @default.
• W2020343457 cites W2091595932 @default.
• W2020343457 cites W2091866599 @default.
• W2020343457 cites W2095252431 @default.
• W2020343457 cites W2097744577 @default.
• W2020343457 cites W2104239648 @default.
• W2020343457 cites W2109897978 @default.
• W2020343457 cites W2113704955 @default.
• W2020343457 cites W2139743386 @default.
• W2020343457 cites W2140271695 @default.
• W2020343457 cites W2152272441 @default.
• W2020343457 cites W2153445980 @default.
• W2020343457 cites W2172270516 @default.
• W2020343457 cites W4238813159 @default.
• W2020343457 cites W4244095134 @default.
• W2020343457 cites W4251144546 @default.
• W2020343457 cites W4376596386 @default.
• W2020343457 doi "https://doi.org/10.1371/journal.pone.0056790" @default.
• W2020343457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3574072" @default.
• W2020343457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23457615" @default.
• W2020343457 hasPublicationYear "2013" @default.
• W2020343457 type Work @default.
• W2020343457 sameAs 2020343457 @default.
• W2020343457 citedByCount "19" @default.
• W2020343457 countsByYear W20203434572014 @default.
• W2020343457 countsByYear W20203434572015 @default.
• W2020343457 countsByYear W20203434572017 @default.
• W2020343457 countsByYear W20203434572018 @default.
• W2020343457 countsByYear W20203434572019 @default.
• W2020343457 countsByYear W20203434572020 @default.
• W2020343457 countsByYear W20203434572021 @default.
• W2020343457 countsByYear W20203434572022 @default.
• W2020343457 countsByYear W20203434572023 @default.
• W2020343457 crossrefType "journal-article" @default.
• W2020343457 hasAuthorship W2020343457A5034693624 @default.
• W2020343457 hasAuthorship W2020343457A5052739966 @default.
• W2020343457 hasAuthorship W2020343457A5076289593 @default.
• W2020343457 hasAuthorship W2020343457A5082900373 @default.
• W2020343457 hasAuthorship W2020343457A5083217078 @default.
• W2020343457 hasAuthorship W2020343457A5091418914 @default.
• W2020343457 hasBestOaLocation W20203434571 @default.
• W2020343457 hasConcept C104317684 @default.
• W2020343457 hasConcept C105702510 @default.
• W2020343457 hasConcept C126322002 @default.
• W2020343457 hasConcept C142724271 @default.
• W2020343457 hasConcept C150903083 @default.
• W2020343457 hasConcept C153074725 @default.
• W2020343457 hasConcept C16685009 @default.
• W2020343457 hasConcept C169760540 @default.
• W2020343457 hasConcept C185592680 @default.
• W2020343457 hasConcept C202751555 @default.
• W2020343457 hasConcept C204232928 @default.
• W2020343457 hasConcept C207001950 @default.
• W2020343457 hasConcept C2776378700 @default.
• W2020343457 hasConcept C2776819169 @default.
• W2020343457 hasConcept C2778041096 @default.

• next