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• W2020346225 abstract "For improved detection of diverse posttranslational modifications (PTMs), direct fragmentation of protein ions by top down mass spectrometry holds promise but has yet to be achieved on a large scale. Using lysate from Saccharomyces cerevisiae, 117 gene products were identified with 100% sequence coverage revealing 26 acetylations, 1 N-terminal dimethylation, 1 phosphorylation, 18 duplicate genes, and 44 proteolytic fragments. The platform for this study combined continuous-elution gel electrophoresis, reversed-phase liquid chromatography, automated nanospray coupled with a quadrupole-FT hybrid mass spectrometer, and a new search engine for querying a custom database. The proteins identified required no manual validation, ranged from 5 to 39 kDa, had codon biases from 0.93 to 0.083, and were primarily associated with glycolysis and protein synthesis. Illustrations of gene-specific identifications, PTM detection and subsequent PTM localization (using either electron capture dissociation or known PTM data stored in a database) show how larger scale proteome projects incorporating top down may proceed in the future using commercial Q-FT instruments." @default.
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• W2020346225 date "2004-04-14" @default.
• W2020346225 modified "2023-10-13" @default.
• W2020346225 title "Molecular-Level Description of Proteins from <i>Saccharomyces c</i><i>erevisiae</i> Using Quadrupole FT Hybrid Mass Spectrometry for Top Down Proteomics" @default.
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• W2020346225 doi "https://doi.org/10.1021/ac0354903" @default.
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