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• W2020346259 abstract "Thermogenic UCP1-positive cells, which include brown and beige adipocytes, transform chemical energy into heat and increase whole-body energy expenditure. Using a ribosomal profiling approach, we present a comprehensive molecular description of brown and beige gene expression from multiple fat depots in vivo. This UCP1-TRAP data set demonstrates striking similarities and important differences between these cell types, including a smooth muscle-like signature expressed by beige, but not classical brown, adipocytes. In vivo fate mapping using either a constitutive or an inducible Myh11-driven Cre demonstrates that at least a subset of beige cells arise from a smooth muscle-like origin. Finally, ectopic expression of PRDM16 converts bona fide vascular smooth muscle cells into Ucp1-positive adipocytes in vitro. These results establish a portrait of brown and beige adipocyte gene expression in vivo and identify a smooth muscle-like origin for beige cells." @default.
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• W2020346259 date "2014-05-01" @default.
• W2020346259 modified "2023-10-16" @default.
• W2020346259 title "A Smooth Muscle-Like Origin for Beige Adipocytes" @default.
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• W2020346259 doi "https://doi.org/10.1016/j.cmet.2014.03.025" @default.
• W2020346259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4052772" @default.
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