Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020356504> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2020356504 endingPage "837" @default.
- W2020356504 startingPage "827" @default.
- W2020356504 abstract "The telomerase enzyme adds simple sequence repeats to chromosome ends. Telomerases share two essential subunits, telomerase RNA and telomerase reverse transcriptase, that associate with species-specific proteins of predominantly unknown functions. The Tetrahymena p80/p95 complex can coimmunopurify active telomerase from cell extract, and recombinant p80/p95 can interact directly with telomerase RNA and single-stranded telomeric DNA in vitro. Here, we test the functions of p80/p95 in vivo. Surprisingly, telomerase RNA accumulation and telomerase activity in cell extract are unaffected by loss of the genes encoding p80/p95. However, in the absence of p80/p95, telomeres become elongated in both macronuclei and micronuclei. Micronuclear chromosome maintenance is also compromised. These findings suggest that p80/p95 functions to maintain appropriate telomere length and micronuclear genomic stability but does so in a manner different than previously anticipated." @default.
- W2020356504 created "2016-06-24" @default.
- W2020356504 creator A5025220040 @default.
- W2020356504 creator A5086985222 @default.
- W2020356504 date "2000-10-01" @default.
- W2020356504 modified "2023-09-26" @default.
- W2020356504 title "The Tetrahymena p80/p95 Complex Is Required for Proper Telomere Length Maintenance and Micronuclear Genome Stability" @default.
- W2020356504 cites W1514461091 @default.
- W2020356504 cites W176521956 @default.
- W2020356504 cites W1820559166 @default.
- W2020356504 cites W1927581912 @default.
- W2020356504 cites W1948628402 @default.
- W2020356504 cites W1974306631 @default.
- W2020356504 cites W1975716080 @default.
- W2020356504 cites W1998405157 @default.
- W2020356504 cites W2007663749 @default.
- W2020356504 cites W2035499819 @default.
- W2020356504 cites W2035953509 @default.
- W2020356504 cites W2037654635 @default.
- W2020356504 cites W2046892466 @default.
- W2020356504 cites W2077449437 @default.
- W2020356504 cites W2089362593 @default.
- W2020356504 cites W2092446580 @default.
- W2020356504 cites W2110727184 @default.
- W2020356504 cites W2111723163 @default.
- W2020356504 cites W2124939132 @default.
- W2020356504 cites W2127833525 @default.
- W2020356504 cites W2133195916 @default.
- W2020356504 cites W2142298035 @default.
- W2020356504 cites W2143318037 @default.
- W2020356504 cites W2145932272 @default.
- W2020356504 doi "https://doi.org/10.1016/s1097-2765(05)00078-x" @default.
- W2020356504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11090621" @default.
- W2020356504 hasPublicationYear "2000" @default.
- W2020356504 type Work @default.
- W2020356504 sameAs 2020356504 @default.
- W2020356504 citedByCount "31" @default.
- W2020356504 countsByYear W20203565042013 @default.
- W2020356504 countsByYear W20203565042014 @default.
- W2020356504 countsByYear W20203565042019 @default.
- W2020356504 crossrefType "journal-article" @default.
- W2020356504 hasAuthorship W2020356504A5025220040 @default.
- W2020356504 hasAuthorship W2020356504A5086985222 @default.
- W2020356504 hasBestOaLocation W20203565041 @default.
- W2020356504 hasConcept C104317684 @default.
- W2020356504 hasConcept C125593758 @default.
- W2020356504 hasConcept C153911025 @default.
- W2020356504 hasConcept C156719811 @default.
- W2020356504 hasConcept C177336024 @default.
- W2020356504 hasConcept C2777166614 @default.
- W2020356504 hasConcept C34558173 @default.
- W2020356504 hasConcept C54355233 @default.
- W2020356504 hasConcept C67705224 @default.
- W2020356504 hasConcept C86803240 @default.
- W2020356504 hasConcept C94581717 @default.
- W2020356504 hasConcept C95444343 @default.
- W2020356504 hasConceptScore W2020356504C104317684 @default.
- W2020356504 hasConceptScore W2020356504C125593758 @default.
- W2020356504 hasConceptScore W2020356504C153911025 @default.
- W2020356504 hasConceptScore W2020356504C156719811 @default.
- W2020356504 hasConceptScore W2020356504C177336024 @default.
- W2020356504 hasConceptScore W2020356504C2777166614 @default.
- W2020356504 hasConceptScore W2020356504C34558173 @default.
- W2020356504 hasConceptScore W2020356504C54355233 @default.
- W2020356504 hasConceptScore W2020356504C67705224 @default.
- W2020356504 hasConceptScore W2020356504C86803240 @default.
- W2020356504 hasConceptScore W2020356504C94581717 @default.
- W2020356504 hasConceptScore W2020356504C95444343 @default.
- W2020356504 hasIssue "4" @default.
- W2020356504 hasLocation W20203565041 @default.
- W2020356504 hasLocation W20203565042 @default.
- W2020356504 hasOpenAccess W2020356504 @default.
- W2020356504 hasPrimaryLocation W20203565041 @default.
- W2020356504 hasRelatedWork W1420010225 @default.
- W2020356504 hasRelatedWork W1545382769 @default.
- W2020356504 hasRelatedWork W1979900842 @default.
- W2020356504 hasRelatedWork W2007052116 @default.
- W2020356504 hasRelatedWork W2079086572 @default.
- W2020356504 hasRelatedWork W2231912876 @default.
- W2020356504 hasRelatedWork W2736592142 @default.
- W2020356504 hasRelatedWork W2804966765 @default.
- W2020356504 hasRelatedWork W3106737507 @default.
- W2020356504 hasRelatedWork W48385096 @default.
- W2020356504 hasVolume "6" @default.
- W2020356504 isParatext "false" @default.
- W2020356504 isRetracted "false" @default.
- W2020356504 magId "2020356504" @default.
- W2020356504 workType "article" @default.