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- W2020360906 abstract "We report the use of total internal reflection fluorescence (TIRF) microscopy for analyzing receptor pharmacology and the development of a microplate-compatible TIRF imaging system. Using stably expressed green fluorescence protein tagged β2-adrenergic receptor as the reporter, we found that the activation of different receptors results in distinct kinetic signatures of the TIRF intensity of cells. These TIRF signatures closely resemble the characteristics of their respective label-free dynamic mass redistribution signals in the same cells. This suggests that TIRF in microplate can be used for profiling and screening drugs." @default.
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- W2020360906 date "2013-05-13" @default.
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- W2020360906 title "Microplate-compatible total internal reflection fluorescence microscopy for receptor pharmacology" @default.
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- W2020360906 doi "https://doi.org/10.1063/1.4805041" @default.
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