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- W2020364088 abstract "To examine fibroblast growth factor-2 (FGF-2) immunoreactivity in the nucleus ambiguus (NA) after three different recurrent laryngeal nerve (RLN) injuries.Immunohistochemical analysis of FGF-2.Thirty adult rats underwent left-sided RLN crush (group A). The left RLN was transected in groups B (n = 30) and C (n = 30); in group C, both nerve stumps were covered with silicone caps. FGF-2 in the NA was assessed as the ratio of the positive areas on the left (operated [O]) and right (unoperated [U]) sides. The ratio (O/U) was measured 1, 3, 7, 14, and 28 days after the procedure. Three rats underwent left-sided RLN exposure and were killed 7 days later (control).Left-sided RLN paralysis occurred until day 28 in group A. In the control group, O/U was approximately 1. In group A, O/U was significantly elevated on day 7; in group B, on days 3, 7, and 14; and in group C, on day 3. O/U in group B was significantly greater than that in group A on days 14 and 28. Maximal FGF-2 immunoreactivity was significantly lower in group C than in groups A and B.We demonstrated elevated production of FGF-2 in the NA after RLN injury. This endogenous FGF-2 might contribute to preventing lesion-induced neuronal death. Blockage of axonal regeneration might suppress FGF-2 production in the NA. Further understanding of the roles of FGF-2 after RLN injury may contribute to the prevention of neuronal death and facilitation of axonal regeneration." @default.
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- W2020364088 date "2000-12-01" @default.
- W2020364088 modified "2023-10-10" @default.
- W2020364088 title "Expression of Fibroblast Growth Factor-2 in the Nucleus Ambiguus Following Recurrent Laryngeal Nerve Injury in the Rat" @default.
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- W2020364088 doi "https://doi.org/10.1097/00005537-200012000-00030" @default.
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