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- W2020365024 startingPage "e99635" @default.
- W2020365024 abstract "One distinctive feature of Purkinje cells is that they have two types of discharge: in addition to simple spikes they fire complex spikes in response to input from the climbing fibers. These complex spikes have an initial rapid burst of spikes and spikelets followed by a sustained depolarization; in some models of cerebellar function this climbing fiber input supervises learning in Purkinje cells. On the other hand, synaptic plasticity is often thought to rely on the timing of pre-synaptic and post-synaptic spikes. It is suggested here that the period of depolarization following a complex spike, combined with a simple spike-timing-dependent plasticity rule, gives a mechanism for the climbing fiber to supervise learning in the Purkinje cell. This proposal is illustrated using a simple simulation in which it is seen that the climbing fiber succeeds in supervising the learning." @default.
- W2020365024 created "2016-06-24" @default.
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- W2020365024 date "2014-06-19" @default.
- W2020365024 modified "2023-10-14" @default.
- W2020365024 title "Supervised Learning with Complex Spikes and Spike-Timing-Dependent Plasticity" @default.
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- W2020365024 doi "https://doi.org/10.1371/journal.pone.0099635" @default.
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