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- W2020366194 abstract "<i>Background:</i> Most fluoroquinolones have shown limited effectiveness against anaerobic bacteria. Evidence for a multidrug efflux pump, like those involved in fluoroquinolone resistance in some other bacteria, was investigated in <i>Clostridium hathewayi. </i><i>Methods:</i>A parent strain of <i>C.</i><i>hathewayi </i>wasisolated from human intestinal microflora on a medium with a low concentration of norfloxacin and a mutant strain was selected from it on a medium with a high concentration of norfloxacin. Fluoroquinolone sensitivity, drug accumulation, and the effects of different concentrations of fluoroquinolones on the kinetics of growth in the presence and absence of efflux pump inhibitors were measured. <i>Results:</i> Both strains were resistant to several fluoroquinolones and dyes. The pump inhibitor reserpine increased the sensitivity of both strains to some drugs; it affected the growth kinetics and the efflux of norfloxacin and ethidium bromide. <i>Conclusion:</i> The efflux of fluoroquinolone appears to be one reason for fluoroquinolone resistance in<i>C. hathewayi</i>." @default.
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- W2020366194 title "Evidence for Active Drug Efflux in Fluoroquinolone Resistance in <i>Clostridium hathewayi</i>" @default.
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- W2020366194 doi "https://doi.org/10.1159/000087253" @default.
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