Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020366329> ?p ?o ?g. }
- W2020366329 endingPage "54" @default.
- W2020366329 startingPage "49" @default.
- W2020366329 abstract "Purpose of review A variety of novel asthma treatments have been developed based on phenotypes, and the clinical trial results show promising responses. This review summarizes the current knowledge of biomarkers for the determination of asthma phenotypes. Recent findings Eosinophilic inflammation is the most focused phenotype because most novel asthma treatments have targeted T-helper type 2 (Th2) pathway. Fractional-exhaled nitric oxide (FeNO) is a new method that represents an eosinophilic airway inflammation with a significant correlation with sputum eosinophilia and asthma severity instead of sputum eosinophil count that easily influenced by corticosteroid therapy. However, some reports indicated the discordance between treatment response or adjustment and FeNO levels. Serum periostin is a strong serum biomarker for eosinophilic airway inflammation and an indicator of Th2-targeted therapy (such as lebrikizumab or omalizumab) and airflow limitation. YKL-40 is associated with asthma severity and airway remodeling. In addition, genetic and metabolomic approaches have been made to determine asthma phenotypes and severity. Summary Biomarkers such as FeNO and serum periostin represent eosinophilic airway inflammation, together with eosinophil-derived neurotoxin and osteopontin (OPN) needed more replication studies. Periostin, YKL-40, OPN and some metabolites (choline, arginine, acetone and protectin D1) are related to asthma severity and airflow limitation." @default.
- W2020366329 created "2016-06-24" @default.
- W2020366329 creator A5038852974 @default.
- W2020366329 creator A5044524626 @default.
- W2020366329 creator A5046769883 @default.
- W2020366329 creator A5075806390 @default.
- W2020366329 date "2014-02-01" @default.
- W2020366329 modified "2023-10-07" @default.
- W2020366329 title "Adult asthma biomarkers" @default.
- W2020366329 cites W1518421316 @default.
- W2020366329 cites W1910862521 @default.
- W2020366329 cites W1939910265 @default.
- W2020366329 cites W1968921617 @default.
- W2020366329 cites W1988758075 @default.
- W2020366329 cites W1989626763 @default.
- W2020366329 cites W1989948926 @default.
- W2020366329 cites W1993136355 @default.
- W2020366329 cites W1995124093 @default.
- W2020366329 cites W1996391855 @default.
- W2020366329 cites W2002998653 @default.
- W2020366329 cites W2016251536 @default.
- W2020366329 cites W2020537288 @default.
- W2020366329 cites W2022985442 @default.
- W2020366329 cites W2029834141 @default.
- W2020366329 cites W2032110591 @default.
- W2020366329 cites W2038777547 @default.
- W2020366329 cites W2042100605 @default.
- W2020366329 cites W2050171685 @default.
- W2020366329 cites W2055418771 @default.
- W2020366329 cites W2060528829 @default.
- W2020366329 cites W2063037874 @default.
- W2020366329 cites W2063801679 @default.
- W2020366329 cites W2067324660 @default.
- W2020366329 cites W2075868050 @default.
- W2020366329 cites W2088633035 @default.
- W2020366329 cites W2090028381 @default.
- W2020366329 cites W2100578775 @default.
- W2020366329 cites W2105435791 @default.
- W2020366329 cites W2106715003 @default.
- W2020366329 cites W2108354621 @default.
- W2020366329 cites W2108828535 @default.
- W2020366329 cites W2110523555 @default.
- W2020366329 cites W2111940641 @default.
- W2020366329 cites W2117187380 @default.
- W2020366329 cites W2121954044 @default.
- W2020366329 cites W2127303736 @default.
- W2020366329 cites W2127482775 @default.
- W2020366329 cites W2133624639 @default.
- W2020366329 cites W2134338459 @default.
- W2020366329 cites W2136217281 @default.
- W2020366329 cites W2138538481 @default.
- W2020366329 cites W2142082641 @default.
- W2020366329 cites W2150035260 @default.
- W2020366329 cites W2150862403 @default.
- W2020366329 cites W2154263136 @default.
- W2020366329 cites W2156136186 @default.
- W2020366329 cites W2158206794 @default.
- W2020366329 cites W2159556553 @default.
- W2020366329 cites W2166102027 @default.
- W2020366329 doi "https://doi.org/10.1097/aci.0000000000000028" @default.
- W2020366329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24300416" @default.
- W2020366329 hasPublicationYear "2014" @default.
- W2020366329 type Work @default.
- W2020366329 sameAs 2020366329 @default.
- W2020366329 citedByCount "51" @default.
- W2020366329 countsByYear W20203663292014 @default.
- W2020366329 countsByYear W20203663292015 @default.
- W2020366329 countsByYear W20203663292016 @default.
- W2020366329 countsByYear W20203663292017 @default.
- W2020366329 countsByYear W20203663292018 @default.
- W2020366329 countsByYear W20203663292019 @default.
- W2020366329 countsByYear W20203663292020 @default.
- W2020366329 countsByYear W20203663292021 @default.
- W2020366329 countsByYear W20203663292022 @default.
- W2020366329 countsByYear W20203663292023 @default.
- W2020366329 crossrefType "journal-article" @default.
- W2020366329 hasAuthorship W2020366329A5038852974 @default.
- W2020366329 hasAuthorship W2020366329A5044524626 @default.
- W2020366329 hasAuthorship W2020366329A5046769883 @default.
- W2020366329 hasAuthorship W2020366329A5075806390 @default.
- W2020366329 hasConcept C105922876 @default.
- W2020366329 hasConcept C141071460 @default.
- W2020366329 hasConcept C142724271 @default.
- W2020366329 hasConcept C185592680 @default.
- W2020366329 hasConcept C189165786 @default.
- W2020366329 hasConcept C203014093 @default.
- W2020366329 hasConcept C2776042228 @default.
- W2020366329 hasConcept C2776301714 @default.
- W2020366329 hasConcept C2776914184 @default.
- W2020366329 hasConcept C2777037409 @default.
- W2020366329 hasConcept C2777129736 @default.
- W2020366329 hasConcept C2777699602 @default.
- W2020366329 hasConcept C2779758542 @default.
- W2020366329 hasConcept C2780333948 @default.
- W2020366329 hasConcept C2781069245 @default.
- W2020366329 hasConcept C2781142857 @default.
- W2020366329 hasConcept C2781197716 @default.
- W2020366329 hasConcept C55493867 @default.