FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020386120> ?p ?o ?g. }

• W2020386120 endingPage "399" @default.
• W2020386120 startingPage "391" @default.
• W2020386120 abstract "Limited success in the identification of genetic variants underpinning psychiatric illness has prompted attempts to elucidate gene-environment interactions and illness-associated endophenotypes. Here we measured childhood sexual abuse, a potential environmental risk factor, and verbal and visual recall and recognition memory, a possible illness-associated endophenotype in a cohort of bipolar disorder (BPD) subjects and their relatives. We predicted that memory would be affected by sexual trauma and that a number of functional polymorphisms previously implicated in BPD and cognition would moderate the effect of psychological trauma on memory.A cohort of 350 individuals from 47 BPD families was recruited, tested with a neuropsychological battery, and given the Childhood Trauma Questionnaire (CTQ). Eleven different genetic variants previously found to be relevant to BPD or memory dysfunction were typed.As predicted, scores on the sexual abuse scale of the CTQ were negatively associated with memory performance. Furthermore, the low-activity Met allele of the brain-derived neurotrophic factor (BDNF) gene and the epsilon4 allele of the apolipoprotein E gene interacted with sexual abuse scores to result in reduced memory test performance.Apolipoprotein E and BDNF exert a neurotrophic effect in response to cellular injury. Their possible moderation of the association between sexual abuse and memory performance might indicate that there is some degree of overlap in the pathophysiological mechanisms by which psychological and physical trauma impact brain function. The finding of an environmental effect on memory performance and a gene-environment interaction on this hypothetical endophenotype of BPD illustrates the difficulty of identifying genetically and phenotypically simple intermediate traits for molecular genetic studies." @default.
• W2020386120 created "2016-06-24" @default.
• W2020386120 creator A5055089575 @default.
• W2020386120 creator A5056005467 @default.
• W2020386120 creator A5063841533 @default.
• W2020386120 creator A5073216705 @default.
• W2020386120 creator A5080134746 @default.
• W2020386120 date "2007-09-01" @default.
• W2020386120 modified "2023-09-23" @default.
• W2020386120 title "Genotype and Childhood Sexual Trauma Moderate Neurocognitive Performance: A Possible Role for Brain-Derived Neurotrophic Factor and Apolipoprotein E Variants" @default.
• W2020386120 cites W1484497860 @default.
• W2020386120 cites W1551100748 @default.
• W2020386120 cites W1586217971 @default.
• W2020386120 cites W1701655062 @default.
• W2020386120 cites W1914011667 @default.
• W2020386120 cites W1965669283 @default.
• W2020386120 cites W1968888226 @default.
• W2020386120 cites W1974631933 @default.
• W2020386120 cites W1980353834 @default.
• W2020386120 cites W1980587541 @default.
• W2020386120 cites W1984045285 @default.
• W2020386120 cites W1984575214 @default.
• W2020386120 cites W1984737558 @default.
• W2020386120 cites W1986494972 @default.
• W2020386120 cites W1992326063 @default.
• W2020386120 cites W1994950269 @default.
• W2020386120 cites W1995437836 @default.
• W2020386120 cites W1997917663 @default.
• W2020386120 cites W2003586939 @default.
• W2020386120 cites W2009050065 @default.
• W2020386120 cites W2012436641 @default.
• W2020386120 cites W2015098351 @default.
• W2020386120 cites W2019166302 @default.
• W2020386120 cites W2023682802 @default.
• W2020386120 cites W2023731405 @default.
• W2020386120 cites W2027973075 @default.
• W2020386120 cites W2030705868 @default.
• W2020386120 cites W2033333756 @default.
• W2020386120 cites W2035126508 @default.
• W2020386120 cites W2035304341 @default.
• W2020386120 cites W2040577070 @default.
• W2020386120 cites W2040866200 @default.
• W2020386120 cites W2045217506 @default.
• W2020386120 cites W2054019486 @default.
• W2020386120 cites W2062682953 @default.
• W2020386120 cites W2063616597 @default.
• W2020386120 cites W2064212981 @default.
• W2020386120 cites W2064225954 @default.
• W2020386120 cites W2071128065 @default.
• W2020386120 cites W2076950116 @default.
• W2020386120 cites W2080206396 @default.
• W2020386120 cites W2082464174 @default.
• W2020386120 cites W2083819651 @default.
• W2020386120 cites W2084057171 @default.
• W2020386120 cites W2088842558 @default.
• W2020386120 cites W2089540230 @default.
• W2020386120 cites W2089580877 @default.
• W2020386120 cites W2089953140 @default.
• W2020386120 cites W2092281603 @default.
• W2020386120 cites W2094436185 @default.
• W2020386120 cites W2097583483 @default.
• W2020386120 cites W2105874139 @default.
• W2020386120 cites W2106240132 @default.
• W2020386120 cites W2111038577 @default.
• W2020386120 cites W2117527509 @default.
• W2020386120 cites W2118439943 @default.
• W2020386120 cites W2124793618 @default.
• W2020386120 cites W2125618201 @default.
• W2020386120 cites W2130417276 @default.
• W2020386120 cites W2130685024 @default.
• W2020386120 cites W2142031449 @default.
• W2020386120 cites W2146738944 @default.
• W2020386120 cites W2147817341 @default.
• W2020386120 cites W2162196924 @default.
• W2020386120 cites W2163305295 @default.
• W2020386120 cites W2164424529 @default.
• W2020386120 cites W2164710696 @default.
• W2020386120 cites W2170760271 @default.
• W2020386120 cites W2360484118 @default.
• W2020386120 cites W4294747801 @default.
• W2020386120 doi "https://doi.org/10.1016/j.biopsych.2006.10.017" @default.
• W2020386120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17210134" @default.
• W2020386120 hasPublicationYear "2007" @default.
• W2020386120 type Work @default.
• W2020386120 sameAs 2020386120 @default.
• W2020386120 citedByCount "69" @default.
• W2020386120 countsByYear W20203861202012 @default.
• W2020386120 countsByYear W20203861202013 @default.
• W2020386120 countsByYear W20203861202014 @default.
• W2020386120 countsByYear W20203861202015 @default.
• W2020386120 countsByYear W20203861202016 @default.
• W2020386120 countsByYear W20203861202017 @default.
• W2020386120 countsByYear W20203861202018 @default.
• W2020386120 countsByYear W20203861202019 @default.
• W2020386120 countsByYear W20203861202020 @default.
• W2020386120 countsByYear W20203861202021 @default.
• W2020386120 countsByYear W20203861202022 @default.
• W2020386120 countsByYear W20203861202023 @default.

• next