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- W2020388936 abstract "Summary. A chronic animal model is described which permits for the first time the continuous measurement of uterine artery blood flow velocity in the pregnant guineapig by using a miniaturized Doppler flow probe. Preliminary validation revealed that alterations in actual blood flow are directly and proportionally related to the change in the Doppler shift (r = 0.984) from 0 to 100 ml/h. The velocity signal baseline was as stable as that of systemic blood pressure. Depending upon the individual animal's flow velocity, a deviation of 2–5% from baseline was statistically significant. With experience, >90% of preparations were successful and a 30-day interval was often available for study. Uterine artery flow velocity increased steadily between 45 and 55 days of gestation. Instrumentation did not result in fetal growth retardation. A reduction in flow velocity occurred during general anaesthesia using ketamine and the antianxietal xylazine. In agreement with the reports of other investigators using a different model, both hydralazine and angiotensin II increased uterine blood velocity and adrenaline reduced it." @default.
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- W2020388936 date "1986-05-01" @default.
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- W2020388936 title "Chronic measurement, using a Doppler probe, of uterine artery flow in the gravid guinea-pig" @default.
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- W2020388936 doi "https://doi.org/10.1530/jrf.0.0770247" @default.
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