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• W2020390849 abstract "Agonist-induced regulation of cannabinoid CB1 receptors was examined in HEK-293 cells transfected with CB1 receptors and in neuroblastoma N18TG2 cells that naturally express CB1 receptors. In HEK-293 cells, CB1 receptors internalization proceeded, in parallel, via clathrin-coated pits and caveolae. Simultaneous disruption of both pathways induced compensatory endocytic mechanism(s). In N18TG2 cells, endocytosis was not mediated by caveolae-like membrane domains. Heterologous, opioid-induced, downregulation of CB1 receptors was evident in HEK-293 but not N18TG2 cells. The data demonstrate the existence of multiple pathways of CB1 receptors regulation." @default.
• W2020390849 created "2016-06-24" @default.
• W2020390849 creator A5034907298 @default.
• W2020390849 creator A5069158259 @default.
• W2020390849 date "2003-08-01" @default.
• W2020390849 modified "2023-09-23" @default.
• W2020390849 title "Multiple mechanisms of CB1 cannabinoid receptors regulation" @default.
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• W2020390849 doi "https://doi.org/10.1016/s0006-8993(03)02970-6" @default.
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