Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020396346> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2020396346 endingPage "147" @default.
- W2020396346 startingPage "141" @default.
- W2020396346 abstract "The existence of inhomogeneous distribution of coronary flow with antegrade or retrograde perfusion alone has led to alternating between these delivery routes to maximize their individual benefits. Concern over myocardial damage prevented the simultaneous application of antegrade and retrograde cardioplegic blood delivery. Based upon the predominance of retrograde drainage via Thebesian veins, and evidence that pressure-controlled intermittent coronary sinus occlusion during antegrade cardioplegic delivery enhances its distribution and protective properties, this study tests (a) the hypothesis that simultaneous aortic and coronary sinus perfusion is safe during aortic clamping, and (b) reports initial clinical application of this combined strategy in 174 patients. Five minipigs (25-30 kg) underwent 1 hr of aortic clamping with simultaneous aortic (antegrade) and coronary sinus (retrograde) perfusion at 200 ml/min with normal blood (37 degrees C) before and after 30 minutes of perfusion with either warm (37 degrees C) or cold (4 degrees C) blood cardioplegia (BCP). Furthermore, the combined strategy was used in 174 high-risk patients (NYHA class III-IV) at 3 university hospitals to perform myocardial protection during CABG or valve replacement, or a combination of both. Included were 16 patients in cardiogenic shock and 24 undergoing reoperation. In both the clinical and the experimental studies the coronary sinus pressure was always < 40 mmHg in beating or arrested hearts.Compared to control values (81.4 +/- 0.4% tissue water content), no right-ventricular (80.8 +/- 0.8%) or left-ventricular (79.5 +/- 0.3%) edema developed, no lactate was produced (control: -1.0 +/- 0.5 mg/100 g/min, empty beating: -0.64 +/- 5, and BCP arrest: -8.6 +/- 6.6).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2020396346 created "2016-06-24" @default.
- W2020396346 creator A5001721068 @default.
- W2020396346 creator A5008190285 @default.
- W2020396346 creator A5010932122 @default.
- W2020396346 creator A5019852135 @default.
- W2020396346 creator A5026395409 @default.
- W2020396346 creator A5085742591 @default.
- W2020396346 creator A5087341055 @default.
- W2020396346 date "1994-06-01" @default.
- W2020396346 modified "2023-10-15" @default.
- W2020396346 title "Simultaneous Arterial and Coronary Sinus Cardioplegic Perfusion: an Experimental and Clinical Study" @default.
- W2020396346 doi "https://doi.org/10.1055/s-2007-1016476" @default.
- W2020396346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7940483" @default.
- W2020396346 hasPublicationYear "1994" @default.
- W2020396346 type Work @default.
- W2020396346 sameAs 2020396346 @default.
- W2020396346 citedByCount "27" @default.
- W2020396346 countsByYear W20203963462013 @default.
- W2020396346 countsByYear W20203963462020 @default.
- W2020396346 crossrefType "journal-article" @default.
- W2020396346 hasAuthorship W2020396346A5001721068 @default.
- W2020396346 hasAuthorship W2020396346A5008190285 @default.
- W2020396346 hasAuthorship W2020396346A5010932122 @default.
- W2020396346 hasAuthorship W2020396346A5019852135 @default.
- W2020396346 hasAuthorship W2020396346A5026395409 @default.
- W2020396346 hasAuthorship W2020396346A5085742591 @default.
- W2020396346 hasAuthorship W2020396346A5087341055 @default.
- W2020396346 hasConcept C126322002 @default.
- W2020396346 hasConcept C146957229 @default.
- W2020396346 hasConcept C158846371 @default.
- W2020396346 hasConcept C164705383 @default.
- W2020396346 hasConcept C178853913 @default.
- W2020396346 hasConcept C2776850375 @default.
- W2020396346 hasConcept C2777055891 @default.
- W2020396346 hasConcept C2777862461 @default.
- W2020396346 hasConcept C2778165595 @default.
- W2020396346 hasConcept C2778259205 @default.
- W2020396346 hasConcept C2779389133 @default.
- W2020396346 hasConcept C2781300812 @default.
- W2020396346 hasConcept C42219234 @default.
- W2020396346 hasConcept C500558357 @default.
- W2020396346 hasConcept C71924100 @default.
- W2020396346 hasConceptScore W2020396346C126322002 @default.
- W2020396346 hasConceptScore W2020396346C146957229 @default.
- W2020396346 hasConceptScore W2020396346C158846371 @default.
- W2020396346 hasConceptScore W2020396346C164705383 @default.
- W2020396346 hasConceptScore W2020396346C178853913 @default.
- W2020396346 hasConceptScore W2020396346C2776850375 @default.
- W2020396346 hasConceptScore W2020396346C2777055891 @default.
- W2020396346 hasConceptScore W2020396346C2777862461 @default.
- W2020396346 hasConceptScore W2020396346C2778165595 @default.
- W2020396346 hasConceptScore W2020396346C2778259205 @default.
- W2020396346 hasConceptScore W2020396346C2779389133 @default.
- W2020396346 hasConceptScore W2020396346C2781300812 @default.
- W2020396346 hasConceptScore W2020396346C42219234 @default.
- W2020396346 hasConceptScore W2020396346C500558357 @default.
- W2020396346 hasConceptScore W2020396346C71924100 @default.
- W2020396346 hasIssue "03" @default.
- W2020396346 hasLocation W20203963461 @default.
- W2020396346 hasLocation W20203963462 @default.
- W2020396346 hasOpenAccess W2020396346 @default.
- W2020396346 hasPrimaryLocation W20203963461 @default.
- W2020396346 hasRelatedWork W2039501279 @default.
- W2020396346 hasRelatedWork W2067050307 @default.
- W2020396346 hasRelatedWork W2088786055 @default.
- W2020396346 hasRelatedWork W2348838421 @default.
- W2020396346 hasRelatedWork W2358512537 @default.
- W2020396346 hasRelatedWork W2384054992 @default.
- W2020396346 hasRelatedWork W2393936235 @default.
- W2020396346 hasRelatedWork W242472561 @default.
- W2020396346 hasRelatedWork W4254896257 @default.
- W2020396346 hasRelatedWork W4386139324 @default.
- W2020396346 hasVolume "42" @default.
- W2020396346 isParatext "false" @default.
- W2020396346 isRetracted "false" @default.
- W2020396346 magId "2020396346" @default.
- W2020396346 workType "article" @default.