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- W2020404858 abstract "Osteosarcoma is an aggressive pediatric tumor of growing bones that, despite surgery and chemotherapy, is prone to relapse. These mesenchymal tumors are derived from progenitor cells in the osteoblast lineage that have accumulated mutations to escape cell cycle checkpoints leading to excessive proliferation and defects in their ability to differentiate appropriately into mature bone-forming osteoblasts. Like other malignant tumors, osteosarcoma is often heterogeneous, consisting of phenotypically distinct cells with features of different stages of differentiation. The cancer stem cell hypothesis posits that tumors are maintained by stem cells and it is the incomplete eradication of a refractory population of tumor-initiating stem cells that accounts for drug resistance and tumor relapse. In this review we present our current knowledge about the biology of osteosarcoma stem cells from mouse and human tumors, highlighting new insights and unresolved issues in the identification of this elusive population. We focus on factors and pathways that are implicated in maintaining such cells, and differences from paradigms of epithelial cancers. Targeting of the cancer stem cells in osteosarcoma is a promising avenue to explore to develop new therapies for this devastating childhood cancer." @default.
- W2020404858 created "2016-06-24" @default.
- W2020404858 creator A5020124533 @default.
- W2020404858 creator A5085852756 @default.
- W2020404858 creator A5091002644 @default.
- W2020404858 date "2013-09-01" @default.
- W2020404858 modified "2023-09-25" @default.
- W2020404858 title "Perspectives on cancer stem cells in osteosarcoma" @default.
- W2020404858 cites W1546114439 @default.
- W2020404858 cites W181426613 @default.
- W2020404858 cites W1967304777 @default.
- W2020404858 cites W1967861242 @default.
- W2020404858 cites W1983663906 @default.
- W2020404858 cites W1985716810 @default.
- W2020404858 cites W1986034385 @default.
- W2020404858 cites W1988487025 @default.
- W2020404858 cites W1991095294 @default.
- W2020404858 cites W1991255873 @default.
- W2020404858 cites W1994812668 @default.
- W2020404858 cites W2003946870 @default.
- W2020404858 cites W2004419844 @default.
- W2020404858 cites W2006806983 @default.
- W2020404858 cites W2008432341 @default.
- W2020404858 cites W2012038722 @default.
- W2020404858 cites W2017598664 @default.
- W2020404858 cites W2017828716 @default.
- W2020404858 cites W2018321310 @default.
- W2020404858 cites W2018429029 @default.
- W2020404858 cites W2019356007 @default.
- W2020404858 cites W2020131167 @default.
- W2020404858 cites W2020617188 @default.
- W2020404858 cites W2020711428 @default.
- W2020404858 cites W2023152589 @default.
- W2020404858 cites W2023269839 @default.
- W2020404858 cites W2023560061 @default.
- W2020404858 cites W2025109766 @default.
- W2020404858 cites W2025373202 @default.
- W2020404858 cites W2027239974 @default.
- W2020404858 cites W2032021593 @default.
- W2020404858 cites W2035226186 @default.
- W2020404858 cites W2042545863 @default.
- W2020404858 cites W2046856549 @default.
- W2020404858 cites W2046916147 @default.
- W2020404858 cites W2048752843 @default.
- W2020404858 cites W2051729004 @default.
- W2020404858 cites W2055529283 @default.
- W2020404858 cites W2056680337 @default.
- W2020404858 cites W2058569154 @default.
- W2020404858 cites W2058599691 @default.
- W2020404858 cites W2066646758 @default.
- W2020404858 cites W2067632356 @default.
- W2020404858 cites W2067872631 @default.
- W2020404858 cites W2068627477 @default.
- W2020404858 cites W2068923084 @default.
- W2020404858 cites W2069264443 @default.
- W2020404858 cites W2069372797 @default.
- W2020404858 cites W2069381736 @default.
- W2020404858 cites W2073859062 @default.
- W2020404858 cites W2077203163 @default.
- W2020404858 cites W2077559627 @default.
- W2020404858 cites W2079356804 @default.
- W2020404858 cites W2081620485 @default.
- W2020404858 cites W2090117256 @default.
- W2020404858 cites W2090807626 @default.
- W2020404858 cites W2090982381 @default.
- W2020404858 cites W2093049275 @default.
- W2020404858 cites W2095885501 @default.
- W2020404858 cites W2101027724 @default.
- W2020404858 cites W2102085111 @default.
- W2020404858 cites W2102750214 @default.
- W2020404858 cites W2106316818 @default.
- W2020404858 cites W2107908886 @default.
- W2020404858 cites W2109354688 @default.
- W2020404858 cites W2111048208 @default.
- W2020404858 cites W2111920812 @default.
- W2020404858 cites W2115590702 @default.
- W2020404858 cites W2117692326 @default.
- W2020404858 cites W2117738408 @default.
- W2020404858 cites W2118471037 @default.
- W2020404858 cites W2119462927 @default.
- W2020404858 cites W2119962765 @default.
- W2020404858 cites W2123745849 @default.
- W2020404858 cites W2129567747 @default.
- W2020404858 cites W2130746209 @default.
- W2020404858 cites W2131598671 @default.
- W2020404858 cites W2131695680 @default.
- W2020404858 cites W2137790111 @default.
- W2020404858 cites W2139958117 @default.
- W2020404858 cites W2140987848 @default.
- W2020404858 cites W2142136189 @default.
- W2020404858 cites W2146473087 @default.
- W2020404858 cites W2148394396 @default.
- W2020404858 cites W2148855636 @default.
- W2020404858 cites W2149812033 @default.
- W2020404858 cites W2150301699 @default.
- W2020404858 cites W2150479858 @default.
- W2020404858 cites W2151453790 @default.
- W2020404858 cites W2152987563 @default.