Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020408026> ?p ?o ?g. }
- W2020408026 abstract "How signaling domains form is an important, largely unexplored question. We show that ciliary proteins help establish two contiguous, yet distinct cGMP signaling compartments in C. elegans thermosensory AFD neurons. One compartment, a bona fide cilium, is delineated by Bardet-Biedl syndrome (BBS), Meckel syndrome and nephronophthis is associated proteins at its base, and requires Inversin/NPHP-2 to anchor a cGMP-gated ion channel within the proximal ciliary region. The other, a subcompartment with profuse microvilli and different lipid environment, is separated from the dendrite by a cellular junction and requires BBS-8 and DAF-25/Ankmy2 for correct localization of guanylyl cyclases needed for thermosensation. Consistent with a requirement for a membrane diffusion barrier at the subcompartment base, we reveal the unexpected presence of ciliary transition zone proteins where no canonical transition zone ultrastructure exists. We propose that differential compartmentalization of signal transduction components by ciliary proteins is important for the functions of ciliated sensory neurons." @default.
- W2020408026 created "2016-06-24" @default.
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- W2020408026 date "2014-01-01" @default.
- W2020408026 modified "2023-10-18" @default.
- W2020408026 title "Ciliopathy proteins establish a bipartite signaling compartment in a<i>C. elegans</i>thermosensory neuron" @default.
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- W2020408026 doi "https://doi.org/10.1242/jcs.157610" @default.
- W2020408026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4265742" @default.
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