FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020409315> ?p ?o ?g. }

• W2020409315 endingPage "172" @default.
• W2020409315 startingPage "167" @default.
• W2020409315 abstract "Immunological interventions in endotoxemia and sepsis have been tested in experimental and clinical studies. Our group evaluated the effects of an immunoglobulin (Ig)M-enriched solution in an established model of Gram-negative bacteraemia. Ten New Zealand White rabbits (2 - 3 kg) were randomized to a treatment or control group. In both groups, LPS was infused at a rate of 40 mg kg−1 h−1. Immunoglobulin M-enriched solution (Pentaglobin; 2 mL kg−1 h−1) was applied in the intervention group 15 min after beginning LPS infusion. 1 × 108 colony forming units of Escherichia coli were injected 30 min after LPS infusion was commenced. Baseline hemodynamic and respiratory parameters, blood E. coli concentration (30 min before and 1, 15, 30, 60, 90, 120, and 180 min after E. coli injection), polymorphonuclear neutrophil oxidative burst activity, and phagocytosis dead space (both 30 min before and 1, 15, 60, 120, and 180 min postinjection) were measured. Ex vivo phagocytosis activity was measured in a separate experiment and evaluated by electron microscopy. Diffuse alveolar damage (DAD) was measured. Organ colonization (kidney, lung, liver, spleen) was assessed in aseptic organ samples. Hemodynamic parameters did not differ between the two groups. Bacterial blood clearance was not influenced by application of IgM-enriched solution. Liver and spleen colonization was significantly reduced in the IgM group. Immunoglobulin M-enriched solution reduced in vitro residual phagocytosis capacity at 30, 90, and 180 min and improved respiratory burst at 180 min. Correspondingly, ex vivo phagocytosis activity as documented by electron microscopy was increased in the IgM group. The sum of all weighted DAD scores (except overdistension) was significantly better in the IgM group (23 ± 5 vs. 30 ± 8). Immunoglobulin M-enriched solution significantly improved six of seven DAD score parameters and reduced liver and spleen E. coli count. Residual phagocytosis capacity was significantly decreased in the IgM group, whereas burst activity was increased, pointing to an increased in vivo phagocytosis efficiency. Short-term IgM-enriched solution intervention had an especially beneficial effect on LPS-induced pulmonary histological changes." @default.
• W2020409315 created "2016-06-24" @default.
• W2020409315 creator A5000675095 @default.
• W2020409315 creator A5014713161 @default.
• W2020409315 creator A5037808517 @default.
• W2020409315 creator A5038796778 @default.
• W2020409315 creator A5043553397 @default.
• W2020409315 creator A5047065923 @default.
• W2020409315 creator A5069166266 @default.
• W2020409315 creator A5071579434 @default.
• W2020409315 date "2008-02-01" @default.
• W2020409315 modified "2023-10-02" @default.
• W2020409315 title "EFFECTS OF IGM-ENRICHED SOLUTION ON POLYMORPHONUCLEAR NEUTROPHIL FUNCTION, BACTERIAL CLEARANCE, AND LUNG HISTOLOGY IN ENDOTOXEMIA" @default.
• W2020409315 cites W1585588122 @default.
• W2020409315 cites W1964544150 @default.
• W2020409315 cites W1975445019 @default.
• W2020409315 cites W1977692928 @default.
• W2020409315 cites W1992900043 @default.
• W2020409315 cites W2006157122 @default.
• W2020409315 cites W2011749570 @default.
• W2020409315 cites W2018366015 @default.
• W2020409315 cites W2022508734 @default.
• W2020409315 cites W2047632277 @default.
• W2020409315 cites W2051028883 @default.
• W2020409315 cites W2061830441 @default.
• W2020409315 cites W2069958596 @default.
• W2020409315 cites W2089834754 @default.
• W2020409315 cites W2091113259 @default.
• W2020409315 cites W2093816949 @default.
• W2020409315 cites W2097838335 @default.
• W2020409315 cites W2098451760 @default.
• W2020409315 cites W2158805423 @default.
• W2020409315 cites W2315343689 @default.
• W2020409315 cites W2324694159 @default.
• W2020409315 cites W2335787271 @default.
• W2020409315 cites W3134561618 @default.
• W2020409315 cites W4232527057 @default.
• W2020409315 cites W4380208417 @default.
• W2020409315 doi "https://doi.org/10.1097/shk.0b013e318067df15" @default.
• W2020409315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17666945" @default.
• W2020409315 hasPublicationYear "2008" @default.
• W2020409315 type Work @default.
• W2020409315 sameAs 2020409315 @default.
• W2020409315 citedByCount "31" @default.
• W2020409315 countsByYear W20204093152012 @default.
• W2020409315 countsByYear W20204093152013 @default.
• W2020409315 countsByYear W20204093152014 @default.
• W2020409315 countsByYear W20204093152015 @default.
• W2020409315 countsByYear W20204093152016 @default.
• W2020409315 countsByYear W20204093152017 @default.
• W2020409315 countsByYear W20204093152018 @default.
• W2020409315 countsByYear W20204093152019 @default.
• W2020409315 countsByYear W20204093152020 @default.
• W2020409315 countsByYear W20204093152021 @default.
• W2020409315 countsByYear W20204093152023 @default.
• W2020409315 crossrefType "journal-article" @default.
• W2020409315 hasAuthorship W2020409315A5000675095 @default.
• W2020409315 hasAuthorship W2020409315A5014713161 @default.
• W2020409315 hasAuthorship W2020409315A5037808517 @default.
• W2020409315 hasAuthorship W2020409315A5038796778 @default.
• W2020409315 hasAuthorship W2020409315A5043553397 @default.
• W2020409315 hasAuthorship W2020409315A5047065923 @default.
• W2020409315 hasAuthorship W2020409315A5069166266 @default.
• W2020409315 hasAuthorship W2020409315A5071579434 @default.
• W2020409315 hasBestOaLocation W20204093151 @default.
• W2020409315 hasConcept C126322002 @default.
• W2020409315 hasConcept C150903083 @default.
• W2020409315 hasConcept C159654299 @default.
• W2020409315 hasConcept C160448771 @default.
• W2020409315 hasConcept C185592680 @default.
• W2020409315 hasConcept C203014093 @default.
• W2020409315 hasConcept C207001950 @default.
• W2020409315 hasConcept C26291073 @default.
• W2020409315 hasConcept C2776553844 @default.
• W2020409315 hasConcept C2777714996 @default.
• W2020409315 hasConcept C2778384902 @default.
• W2020409315 hasConcept C2780091579 @default.
• W2020409315 hasConcept C2780898057 @default.
• W2020409315 hasConcept C2780931953 @default.
• W2020409315 hasConcept C534529494 @default.
• W2020409315 hasConcept C71924100 @default.
• W2020409315 hasConcept C86803240 @default.
• W2020409315 hasConcept C89423630 @default.
• W2020409315 hasConcept C99971728 @default.
• W2020409315 hasConceptScore W2020409315C126322002 @default.
• W2020409315 hasConceptScore W2020409315C150903083 @default.
• W2020409315 hasConceptScore W2020409315C159654299 @default.
• W2020409315 hasConceptScore W2020409315C160448771 @default.
• W2020409315 hasConceptScore W2020409315C185592680 @default.
• W2020409315 hasConceptScore W2020409315C203014093 @default.
• W2020409315 hasConceptScore W2020409315C207001950 @default.
• W2020409315 hasConceptScore W2020409315C26291073 @default.
• W2020409315 hasConceptScore W2020409315C2776553844 @default.
• W2020409315 hasConceptScore W2020409315C2777714996 @default.
• W2020409315 hasConceptScore W2020409315C2778384902 @default.
• W2020409315 hasConceptScore W2020409315C2780091579 @default.
• W2020409315 hasConceptScore W2020409315C2780898057 @default.
• W2020409315 hasConceptScore W2020409315C2780931953 @default.

• next